Document Detail

Neurological manifestations of Behçet's disease in Japan: a study of 54 patients.
MedLine Citation:
PMID:  20127350     Owner:  NLM     Status:  MEDLINE    
The type and frequency of neurological manifestations of Behçet's disease (BD) vary with ethnicity. We analyzed the neurological manifestations of BD in Japanese patients. All patients undergoing treatment at one of the two Yokohama City University hospitals from July 1991 to December 2007 and who fulfilled the Japanese criteria for BD revised in 1987 were studied retrospectively by chart review. Patients had been neurologically assessed by neurologists. We recorded neurological signs and symptoms, magnetic resonance imaging or computed tomography findings, and results of cerebrospinal fluid examinations from the records of each patient. We studied 412 patients with BD, of whom 54 (13%) had neurological involvement (neuro-Behçet's disease: NB). NB patients included a significantly higher proportion of males (61%) than non-NB patients (42%, P = 0.009). The majority of patients (n = 38, 70%) had acute parenchymal NB, 15 (28%) had chronic progressive parenchymal NB, and 1 (2%) had the non-parenchymal type. Headache and fever were more frequently reported by patients with acute parenchymal NB. Personality changes, sphincter disturbances, involuntary movements, and ataxia occurred predominantly in patients with chronic progressive parenchymal NB. Lesions were distributed throughout the CNS, but mainly in the brainstem, white matter, and basal ganglia. Analysis of end-point clinical outcomes revealed a poor prognosis for patients with chronic progressive NB. In Japan, most NB patients have the parenchymal type, and male gender is a predisposing factor. Because of the unfavorable prognosis associated with chronic progressive NB, development of effective therapies are urgently needed.
Haruko Ideguchi; Akiko Suda; Mitsuhiro Takeno; Yohei Kirino; Atsushi Ihata; Atsuhisa Ueda; Shigeru Ohno; Yasuhisa Baba; Yoshiyuki Kuroiwa; Yoshiaki Ishigatsubo
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-02-03
Journal Detail:
Title:  Journal of neurology     Volume:  257     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1012-20     Citation Subset:  IM    
Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan.
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MeSH Terms
Asian Continental Ancestry Group
Behcet Syndrome / epidemiology*,  physiopathology,  therapy
Brain / pathology,  radiography
Chronic Disease
Cranial Nerves / pathology,  radiography
Disease Progression
Nervous System Diseases / epidemiology*,  physiopathology,  therapy
Retrospective Studies
Sex Factors
Spinal Cord / pathology,  radiography
Treatment Outcome

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