| Neurological impairment and arthritis in an immunocompetent child with human parvovirus B19 chronic infection. | |
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MedLine Citation:
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PMID: 20956876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human parvovirus B19 (HPV-B19) is usually a self-limiting infection in immunocompetent children. In this case report, instead, we describe an immunocompotent child with evidence of persistent HPV-B19 infection, arthritis and neurological impairment. He was first admitted to hospital for HPV-B19 infection and sent home in good clinical condition after anti-inflammatory therapy. Eight months later he was re-admitted to hospital for episodes of arthritis and weakness, myalgia, tremors in his legs and hands, and was unable to walk unaided. In both plasma and serum, HPV-B19 DNA, detected by polymerase chain reaction, was still present. For neurological symptoms, he underwent magnetic resonance, which showed increased signal intensity at the spinal roots in the lumbar region, compatible with polyradiculoneuritis. After immunoglobulin therapy he had an excellent response in clinical and radiological terms, suggesting an association between neurological impairment and HPV-B19 infection. Eleven months after the second admission, the patient was still in good clinical condition. |
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Authors:
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Elena Bozzola; Andrzej Krzysztofiak; Eisabetta Cortis |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive Volume: 18 ISSN: 1124-9390 ISO Abbreviation: Infez Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2011-01-24 Revised Date: 2012-02-07 |
Medline Journal Info:
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Nlm Unique ID: 9613961 Medline TA: Infez Med Country: Italy |
Other Details:
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Languages: eng Pagination: 187-90 Citation Subset: IM |
Affiliation:
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Ospedale Bambino Gesu, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ankle Joint
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virology* Arthritis, Infectious / etiology*, therapy Child Chronic Disease Erythema Infectiosum / complications Headache / etiology Humans Immunocompetence Immunoglobulins, Intravenous / therapeutic use Male Parvoviridae Infections / complications*, immunology, therapy, virology Parvovirus B19, Human / isolation & purification* Polyradiculoneuropathy / etiology*, therapy, virology Reflex, Abnormal Viremia / etiology, immunology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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