| Neurological diseases in relation to the blood-brain barrier. | |
| | |
MedLine Citation:
|
PMID: 22252235 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Disruption of the blood-brain barrier (BBB) has an important part in cellular damage in neurological diseases, including acute and chronic cerebral ischemia, brain trauma, multiple sclerosis, brain tumors, and brain infections. The neurovascular unit (NVU) forms the interface between the blood and brain tissues. During an injury, the cascade of molecular events ends in the final common pathway for BBB disruption by free radicals and proteases, which attack membranes and degrade the tight junction proteins in endothelial cells. Free radicals of oxygen and nitrogen and the proteases, matrix metalloproteinases and cyclooxgyenases, are important in the early and delayed BBB disruption as the neuroinflammatory response progresses. Opening of the BBB occurs in neurodegenerative diseases and contributes to the cognitive changes. In addition to the importance of the NVU in acute injury, angiogenesis contributes to the recovery process. The challenges to treatment of the brain diseases involve not only facilitating drug entry into the brain, but also understanding the timing of the molecular cascades to block the early NVU injury without interfering with recovery. This review will describe the molecular and cellular events associated with NVU disruption and potential strategies directed toward restoring its integrity.Journal of Cerebral Blood Flow & Metabolism advance online publication, 18 January 2012; doi:10.1038/jcbfm.2011.197. |
| | |
Authors:
|
Gary A Rosenberg |
Related Documents
:
|
2454305 - Isovolemic hemodilution in experimental focal cerebral ischemia. part 2: effects on reg... 22227085 - Factors associated with acute lung injury in combat casualties receiving massive blood ... 16594145 - Differentiating hemodynamic compromise by the oef response to acetazolamide in occlusiv... 1601775 - Systemic blood flow to the lung after bronchial artery occlusion in anesthetized sheep. 7080135 - Pattern difference of reversed ophthalmic blood flow between occlusion and stenosis of ... 19395205 - Signs of fetal brain sparing are not related to umbilical cord blood gases at birth. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: - ISSN: 1559-7016 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Departments of Neurology, Neurosciences, Cell Biology and Physiology and Mathematics and Statistics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plexin-B1 and semaphorin 4D cooperate to promote perineural invasion in a RhoA/ROK-dependent manner.
Next Document: Preserved acetazolamide reactivity in lacunar patients with severe white-matter lesions: (15)O-label...