| Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya. | |
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MedLine Citation:
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PMID: 16262736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal jaundice (NJ) and sepsis are common causes of neonatal mortality in sub-Saharan Africa, but little is known about the long-term morbidity in this setting. This study aimed to describe the neurological and developmental sequelae of severe neonatal hyperbilirubinaemia and neonatal sepsis (NS) in a district hospital in rural Kenya. Twenty-three term infants with NJ [total serum bilirubin (TSB) >300 mumol/l] and 24 infants with a history of NS were identified from hospital records. These children were compared to 40 children from the community (CC) without neonatal problems. At ages 18-32 months, the children's neurological, motor and developmental status were assessed, and blood groups of the NJ and NS subjects and their mothers were determined. Ten (43%) of the NJ subjects were unable to sit and/or stand independently. The NJ subjects had significantly more neurological, motor and developmental difficulties and caused greater maternal concern than the CCs. Five (21%) of the NJ subjects had possible blood group incompatibility. The NS subjects had significantly more motor and eye-hand difficulties and maternal concerns expressed than the CCs. Severe NJ in term infants (of mainly non-haemolytic origin) was associated with a high prevalence of neurological and developmental sequelae at ages 18-32 months. The NS is also associated with neuro-developmental sequelae, but the pattern is different to those seen in NJ. Since NS is common in resource poor countries, this may be an important cause of neuro-developmental impairment in children living in this setting. |
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Authors:
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Anne L Gordon; Michael English; J Tumaini Dzombo; Mary Karisa; Charles R J C Newton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Tropical medicine & international health : TM & IH Volume: 10 ISSN: 1360-2276 ISO Abbreviation: Trop. Med. Int. Health Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-02 Completed Date: 2005-12-12 Revised Date: 2007-08-13 |
Medline Journal Info:
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Nlm Unique ID: 9610576 Medline TA: Trop Med Int Health Country: England |
Other Details:
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Languages: eng Pagination: 1114-20 Citation Subset: IM |
Affiliation:
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Centre for Geographic Medicine Research--Coast, KEMRI/Wellcome Trust Research Laboratories, Kilifi, Kenya. gordonanne@yahoo.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Damage, Chronic
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etiology Child, Preschool Developmental Disabilities / etiology* Female Hospitalization Humans Infant Infant, Newborn Jaundice, Neonatal / complications* Kenya Motor Activity / physiology Nervous System Diseases / etiology* Neuropsychological Tests Prognosis Psychomotor Disorders / etiology Rural Health Sepsis / complications* Socioeconomic Factors |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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