Document Detail

Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya.
MedLine Citation:
PMID:  16262736     Owner:  NLM     Status:  MEDLINE    
Neonatal jaundice (NJ) and sepsis are common causes of neonatal mortality in sub-Saharan Africa, but little is known about the long-term morbidity in this setting. This study aimed to describe the neurological and developmental sequelae of severe neonatal hyperbilirubinaemia and neonatal sepsis (NS) in a district hospital in rural Kenya. Twenty-three term infants with NJ [total serum bilirubin (TSB) >300 mumol/l] and 24 infants with a history of NS were identified from hospital records. These children were compared to 40 children from the community (CC) without neonatal problems. At ages 18-32 months, the children's neurological, motor and developmental status were assessed, and blood groups of the NJ and NS subjects and their mothers were determined. Ten (43%) of the NJ subjects were unable to sit and/or stand independently. The NJ subjects had significantly more neurological, motor and developmental difficulties and caused greater maternal concern than the CCs. Five (21%) of the NJ subjects had possible blood group incompatibility. The NS subjects had significantly more motor and eye-hand difficulties and maternal concerns expressed than the CCs. Severe NJ in term infants (of mainly non-haemolytic origin) was associated with a high prevalence of neurological and developmental sequelae at ages 18-32 months. The NS is also associated with neuro-developmental sequelae, but the pattern is different to those seen in NJ. Since NS is common in resource poor countries, this may be an important cause of neuro-developmental impairment in children living in this setting.
Anne L Gordon; Michael English; J Tumaini Dzombo; Mary Karisa; Charles R J C Newton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tropical medicine & international health : TM & IH     Volume:  10     ISSN:  1360-2276     ISO Abbreviation:  Trop. Med. Int. Health     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2005-12-12     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  9610576     Medline TA:  Trop Med Int Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  1114-20     Citation Subset:  IM    
Centre for Geographic Medicine Research--Coast, KEMRI/Wellcome Trust Research Laboratories, Kilifi, Kenya.
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MeSH Terms
Brain Damage, Chronic / etiology
Child, Preschool
Developmental Disabilities / etiology*
Infant, Newborn
Jaundice, Neonatal / complications*
Motor Activity / physiology
Nervous System Diseases / etiology*
Neuropsychological Tests
Psychomotor Disorders / etiology
Rural Health
Sepsis / complications*
Socioeconomic Factors
Grant Support
//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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