| Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. | |
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MedLine Citation:
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PMID: 7709410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Occluding a large intracranial artery in rats produces a brain lesion that grows in terms of an increase in both surface area and number of necrotic neurons. The present study investigated whether reperfusing the ischemic territory 30 to 60 minutes after the arterial occlusion would have a beneficial effect on either the clinical or the histological outcome of the lesion. METHODS: One hundred four adult rats (including appropriate controls) were used; 97 had a middle cerebral artery occluded by inserting a nylon monofilament via the right external carotid artery. The arterial occlusion was transient in two groups and permanent in another; survival times were comparable for all groups. Control animals were subjected to a sham operation during which the artery was occluded for less than 1 minute. The outcome was evaluated by measuring the extent of the neurological deficit and the severity of the histological injury. RESULTS: Mean neurological score and mean number of necrotic neurons in the cortex were more favorable after transient (30- to 60-minute) compared with permanent arterial occlusion (P < .005). Moreover, the correlation between mean neurological score and mean number of necrotic neurons was highly significant: r = .951; P < .001. CONCLUSIONS: The histological effects of an intracranial arterial occlusion in the adult rat can be predicted on day 1 by the neurological score described in this report. Significant improvement can be obtained in these animals by reestablishing arterial flow 60 minutes or sooner after the ictus. The pattern of cortical pannecrosis observed after permanent occlusion (> or = 72 hours) was transformed into incomplete ischemic injury in most instances of transient occlusion. |
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Authors:
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J H Garcia; S Wagner; K F Liu; X J Hu |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 26 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-05-09 Completed Date: 1995-05-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 627-34; discussion 635 Citation Subset: IM |
Affiliation:
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Department of Pathology (Neuropathology), Henry Ford Hospital, Detroit, Mich 48202-2689, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / pathology* Brain / pathology* Cerebral Arterial Diseases / pathology* Disease Models, Animal Necrosis Neurologic Examination Rats Rats, Wistar |
| Grant Support | |
ID/Acronym/Agency:
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NS 31631/NS/NINDS NIH HHS |
| Comments/Corrections | |
Comment In:
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Stroke. 1998 Apr;29(4):871-2
[PMID:
9550529
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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