Document Detail

Neurological complications of intravenous immunoglobulin (IVIg) therapy: an illustrative case of acute encephalopathy following IVIg therapy and a review of the literature.
MedLine Citation:
PMID:  9922823     Owner:  NLM     Status:  MEDLINE    
We report the case of a 73-year-old man who developed an acute encephalopathy during IVIg therapy for AIDP. The signs and symptoms of the encephalopathy completely resolved after discontinuation of the treatment. We also reviewed the literature over the major neurological complications of IVIg therapy, including aseptic meningitis, cerebral infarction, and acute encephalopathy. About 30 cases of aseptic meningitis are reported. They are probably related to an immunoallergic reaction, caused by the entry of the exogenous IgG into the CSF compartment. CSF examinations usually show a neutrophilic or a mixed pleocytosis. Three cases of cerebral infarction and 2 patients with acute encephalopathy, following IVIg therapy, were also reported in the literature. Cerebral vasospasm, cerebral vasculitis, and/or serum hyperviscosity may be implicated in the pathogenesis of these neurological complications. There is a clinical similarity between these IVIg-related encephalopathy and the "reversible posterior leukoencephalopathy syndrome", described by Hinchey et al., 1996.
I Mathy; M Gille; F Van Raemdonck; J Delbecq; A Depré
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta neurologica Belgica     Volume:  98     ISSN:  0300-9009     ISO Abbreviation:  Acta Neurol Belg     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-05-04     Completed Date:  1999-05-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0247035     Medline TA:  Acta Neurol Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  347-51     Citation Subset:  IM    
Department of Neurology, Clinique Ste Elisabeth, Brussels, Belgium.
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MeSH Terms
Acute Disease
Brain Diseases / etiology*,  physiopathology,  therapy
Cerebrovascular Disorders / etiology,  physiopathology
Consciousness Disorders / etiology
Facial Paralysis / therapy
Immunoglobulins, Intravenous / adverse effects*
Meningitis, Aseptic / etiology
Plasma Exchange
Polyradiculoneuropathy / therapy
Tremor / etiology
Vision Disorders / etiology
Reg. No./Substance:
0/Immunoglobulins, Intravenous

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