Document Detail

Neurological complications of coronary angiographic procedures.
MedLine Citation:
PMID:  18035927     Owner:  NLM     Status:  MEDLINE    
Neurological complications of coronary angiographic procedures are uncommon, varied and can include central nervous toxicity caused by contrast agents (contrast reactions), as well as ischemic and hemorrhagic stroke. These complications are rare; however, more recent data derived from neuroimaging studies suggest that there is a higher incidence of 'silent' ischemic events. The impact of these subclinical events is still uncertain, but a few studies suggest that long term they may lead to cognitive decline, which is usually subtle. The clinical presentation of both contrast reactions and strokes can, at times, be very similar as there is a higher than expected incidence of posterior circulation involvement with both. While the treatment of contrast reactions is usually supportive, treatment of ischemic stroke in patients undergoing catheterization procedures appears, based on limited case report series, to lead to favorable outcomes with immediate neuroangiographic intervention, including local administration of recombinant-type tissue plasminogen activator.
Ennis J Duffis; David Jones; Dennis Tighe; Majaz Moonis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  5     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-26     Completed Date:  2008-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  1113-21     Citation Subset:  IM    
Department of Neurology, UMass Memorial Medical Center, 55 Lake Avenue North, Worcester, MA 01655, USA.
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MeSH Terms
Brain Ischemia / drug therapy,  epidemiology,  etiology*
Coronary Angiography / adverse effects*,  methods
Coronary Artery Disease / diagnosis
Follow-Up Studies
Heart Catheterization / adverse effects*,  methods
Middle Aged
Radiopharmaceuticals / adverse effects,  diagnostic use
Risk Assessment
Stroke / drug therapy,  epidemiology,  etiology*
Survival Analysis
Tissue Plasminogen Activator / therapeutic use*
Reg. No./Substance:
0/Radiopharmaceuticals; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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