Document Detail

Neurological complications of celiac disease: a rare but continuing problem.
MedLine Citation:
PMID:  8678009     Owner:  NLM     Status:  MEDLINE    
Neurological complications are a recognized but unusual manifestation of celiac disease. We present here our experiences with four current cases. Age of patients at presentation with neurological signs varied from 7 to 67 yr. In one patient, the neurological disability developed before the diagnosis of celiac disease, whereas, in the other three, it occurred from months to 16 yr after the diagnosis had been established. One patient died of rapidly progressive neuromyopathy. The other three patients had combinations of cerebellar and posterior and lateral column abnormalities. All four patients developed neurological complications despite a strict gluten-free diet. In three of four patients, there was no improvement in duodenal histology on this diet. Treatment with vitamin B12, folic acid, or vitamin D failed to reverse the changes. No other nutritional deficiencies were found. Vitamin E levels were normal in two of three patients. One patient had no response to treatment with immunosuppressive drugs. The mechanisms responsible for these neurological complications are poorly understood, although patients whose duodenal histology fails to improve on a gluten-free diet may be at greater risk. There have been no real advances in the understanding of this condition since the original description nearly 30 yr ago.
A F Muller; M T Donnelly; C M Smith; M J Grundman; G K Holmes; P J Toghill
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  91     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-09     Completed Date:  1996-08-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1430-5     Citation Subset:  IM    
University Hospital, Nottingham, England.
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MeSH Terms
Aged, 80 and over
Celiac Disease / complications*,  diagnosis,  pathology
Chronic Disease
Disease Progression
Fatal Outcome
Middle Aged
Nervous System Diseases / diagnosis,  etiology*,  pathology
Comment In:
Am J Gastroenterol. 1997 Mar;92(3):540   [PMID:  9068497 ]

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