| Neurological complications of celiac disease: a rare but continuing problem. | |
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MedLine Citation:
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PMID: 8678009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurological complications are a recognized but unusual manifestation of celiac disease. We present here our experiences with four current cases. Age of patients at presentation with neurological signs varied from 7 to 67 yr. In one patient, the neurological disability developed before the diagnosis of celiac disease, whereas, in the other three, it occurred from months to 16 yr after the diagnosis had been established. One patient died of rapidly progressive neuromyopathy. The other three patients had combinations of cerebellar and posterior and lateral column abnormalities. All four patients developed neurological complications despite a strict gluten-free diet. In three of four patients, there was no improvement in duodenal histology on this diet. Treatment with vitamin B12, folic acid, or vitamin D failed to reverse the changes. No other nutritional deficiencies were found. Vitamin E levels were normal in two of three patients. One patient had no response to treatment with immunosuppressive drugs. The mechanisms responsible for these neurological complications are poorly understood, although patients whose duodenal histology fails to improve on a gluten-free diet may be at greater risk. There have been no real advances in the understanding of this condition since the original description nearly 30 yr ago. |
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Authors:
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A F Muller; M T Donnelly; C M Smith; M J Grundman; G K Holmes; P J Toghill |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 91 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-08-09 Completed Date: 1996-08-09 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1430-5 Citation Subset: IM |
Affiliation:
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University Hospital, Nottingham, England. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Celiac Disease / complications*, diagnosis, pathology Chronic Disease Disease Progression Fatal Outcome Female Humans Male Middle Aged Nervous System Diseases / diagnosis, etiology*, pathology |
| Comments/Corrections | |
Comment In:
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Am J Gastroenterol. 1997 Mar;92(3):540
[PMID:
9068497
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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