Document Detail


Neurological complications of celiac disease and autoimmune mechanisms: a prospective study.
MedLine Citation:
PMID:  18343508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Humoral immune mechanisms may have a role in the neurological complications of celiac disease (CD). We assessed 71 CD patients for neurologic manifestations and presence of serum antibodies to neural antigens. Sixteen patients (22.5%) were found to have neurological deficits including headache, depression, entrapment syndromes, peripheral neuropathy, and epilepsy. Antibody reactivity to neural antigens was detected in 30/71 (42.2%) patients. There was no clear correlation between anti-neural reactivity and neurologic dysfunction. Follow-up of 62 patients did not reveal change in electrophysiology or antibodies, regardless of diet. However, in 2 patients with neuropathy, symptoms improved or worsened depending on the diet.
Authors:
Chiara Briani; Gabriella Zara; Armin Alaedini; Francesca Grassivaro; Susanna Ruggero; Elisabetta Toffanin; Maria Paola Albergoni; Milena Luca; Bruno Giometto; Mario Ermani; Franca De Lazzari; Anna D'Odorico; Leontino Battistin
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Publication Detail:
Type:  Journal Article     Date:  2008-03-17
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  195     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-21     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Affiliation:
Department of Neurosciences, University of Padova, Padova, Italy. chiara.briani@unipd.it
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology,  radiation effects
Adult
Antibodies / blood
Blood Cell Count
Celiac Disease / blood,  complications*,  immunology*
Female
Follow-Up Studies
Gangliosides / immunology
Gliadin / immunology
HLA Antigens
Humans
Male
Middle Aged
Nervous System Diseases / blood,  classification,  etiology*,  immunology*
Neural Conduction / physiology
Prospective Studies
Transglutaminases / immunology
Chemical
Reg. No./Substance:
0/Antibodies; 0/Gangliosides; 0/HLA Antigens; 9007-90-3/Gliadin; EC 2.3.2.13/Transglutaminases; EC 2.3.2.13/tissue transglutaminase 2, human

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