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Neurological Soft Signs in Psychotic Patients with cannabis abuse: a systematic review and meta-analysis of the paradox.
MedLine Citation:
PMID:  22716154     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Although neurological soft signs (NSSs) have been consistently associated with schizophrenia and a variety of risk factors, few studies have focused on the association between NSSs and environmental factors such as cannabis use, particularly in patients with first episode psychosis (FEP). Aims: To review studies that have specifically investigated the association between NSSs and cannabis use in subjects who suffer from psychosis, and more specifically in FEP. Methods: A review of studies investigating the associations between neurological function in psychotic patients and cannabis use. Results: A total of 5 studies met our inclusion criteria. Two of these included data only from patients with FEP. Four studies concluded that patients with psychosis and particularly FEP who consumed cannabis showed fewer NSSs. Conclusions: Four possible explanations are suggested for the paradoxical relationship between cannabis use and NSSs in FEP. First, heavy cannabis users present with different acute responses to cannabis use than do occasional cannabis users. Second, the psychoses developed by patients who consume cannabis follow different physio-pathological pathways that include fewer neurodevelopmental abnormalities. Third, the direct effect of cannabis on the Central Nervous System (CNS) may be responsible for the paradox. Finally,severe NSSsare associated with other clinical characteristics that would limit a subjects personal access to cannabis.
Authors:
Miguel Ruiz-Veguilla; Luis F Callado; Maite Ferrin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-07
Journal Detail:
Title:  Current pharmaceutical design     Volume:  -     ISSN:  1873-4286     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Grupo de Investigación Neurodesarrollo y Psicosis. HVR/IBIS. Avda. Manuel Siurot sn. Sevilla. miguel.ruiz.veguilla.sspa@juntadeandalucia.es, maiteferrin@yahoo.es, lf.callado@ehu.es.
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