Document Detail

Neurologic symptoms are common during gestation and puerperium in CADASIL.
MedLine Citation:
PMID:  15851739     Owner:  NLM     Status:  MEDLINE    
Based on a structured questionnaire and medical records, the authors found that 12 of 25 mothers with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with the R133C NOTCH3 mutation had had neurologic symptoms in 17 of their 43 pregnancies, most commonly hemiparesthesia (76%), hemiparesis (36%), aphasia (65%), and visual disorders (47%). In 82% of the patients, the symptoms were the first manifestation of CADASIL. The symptoms were most common during puerperium and in patients older than age 30.
S Roine; M Pöyhönen; S Timonen; S Tuisku; R Marttila; R Sulkava; H Kalimo; M Viitanen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  64     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-26     Completed Date:  2006-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1441-3     Citation Subset:  AIM; IM    
Department of Neurology, University and University Hospital of Turku, Finland.
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MeSH Terms
Aphasia / epidemiology
Brain / blood supply,  pathology,  physiopathology
Brain Ischemia / epidemiology,  physiopathology*
CADASIL / epidemiology,  genetics,  physiopathology*
Cerebral Arteries / pathology,  physiopathology
Cohort Studies
Cross-Sectional Studies
Finland / epidemiology
Paresis / epidemiology
Paresthesia / epidemiology
Postpartum Period
Pre-Eclampsia / epidemiology
Pregnancy Complications / epidemiology,  physiopathology*
Retrospective Studies
Vision Disorders / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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