Document Detail

Neurologic signs of ciguatera disease: evidence of their persistence.
MedLine Citation:
PMID:  18165542     Owner:  NLM     Status:  MEDLINE    
Ciguatoxins exert their effect on the voltage-sensitive sodium channels of the cellular membranes of all excitable tissues. This effect confers to ciguatera disease (CD) its neurologic hallmarks. A prospective study among French Polynesian adults over a two-month period was conducted to characterize and determine the persistence of neurologic symptoms of CD. We compared 47 patients with CD with 125 controls. In the acute phase of the disease, patients had mainly sensory disturbances as detected by an hypoesthesia on the palm of the hand and poorer sway performance compared with controls. Follow-up two months showed improvement of sway performance that eventually reaching control levels. However, for light-touch threshold, even if we observed a decrease threshold towards normal values, more than 50% of patients did not reach normal values 60 days after disease onset. Our results support the existence of neurologic impairments of CD and suggest their persistence for at least two months after onset.
M-L Chateau-Degat; A Beuter; G Vauterin; N L Nguyen; M Chinain; T Darius; A-M Legrand; R Chansin; E Dewailly
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  77     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-31     Completed Date:  2008-02-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1170-5     Citation Subset:  AIM; IM    
Public Health Research Unit, Laval University Medical Research Center, Sainte Foy, Quebec, Canada.
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MeSH Terms
Ciguatera Poisoning / complications*,  physiopathology
Middle Aged
Nervous System Diseases / chemically induced,  etiology*
Postural Balance
Prospective Studies
Sensation Disorders / etiology*
Time Factors

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