Document Detail

Neurologic side effects in neuroleptic-naive patients treated with haloperidol or risperidone.
MedLine Citation:
PMID:  10078728     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the side effect profile of risperidone with that of oral haloperidol in patients with no previous exposure to antipsychotic drugs (APDs). BACKGROUND: Early studies suggested that the APD risperidone may have a side effect profile comparable with that of placebo. These early studies involved patients with chronic schizophrenia and a long history of APD use. Very little information is available regarding the neurologic side effects of risperidone in patients without previous APD exposure. METHODS: The authors prospectively studied 350 consecutive neuroleptic-naive patients admitted to their acute-care psychiatry service; 34 of these were treated with risperidone (mean dose, 3.2 mg/d) and 212 were treated with low-dose haloperidol (mean dose 3.7 mg/d). All patients were assessed on admission and twice weekly thereafter using rating scales for dystonia, parkinsonism, akathisia, and dyskinesia. RESULTS: The incidence and severity of dystonic reactions, akathisia, parkinsonism, and dyskinesia were comparable in the risperidone- and haloperidol-treated groups. CONCLUSIONS: The neurologic side effect profile of low-dose risperidone is comparable with that of haloperidol in patients receiving APDs for the first time. Risperidone may not be a useful alternative to typical APDs for patients with PD and psychosis.
P I Rosebush; M F Mazurek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  52     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-30     Completed Date:  1999-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  782-5     Citation Subset:  AIM; IM    
Department of Psychiatry and Behavioural Neurosciences, McMaster University Medical Centre, Hamilton, Ontario, Canada.
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MeSH Terms
Haloperidol / adverse effects*,  therapeutic use*
Middle Aged
Mood Disorders / drug therapy*
Prospective Studies
Risperidone / adverse effects*,  therapeutic use*
Schizophrenia / drug therapy*
Reg. No./Substance:
106266-06-2/Risperidone; 52-86-8/Haloperidol
Comment In:
Neurology. 2000 Apr 11;54(7):1543-4   [PMID:  10751282 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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