| Neurologic features of Williams and Down syndromes. | |
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MedLine Citation:
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PMID: 2525908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight patients with Williams syndrome and 6 with Down syndrome, matched for age and full-scale IQ, underwent detailed neurologic testing as part of a large multidisciplinary research center study. Williams syndrome patients were small for gestational age and often had histories of failure-to-thrive and feeding problems as infants. Half of the Williams syndrome patients had epilepsy. On neurologic testing, Williams syndrome patients had greater difficulty with gross and fine motor coordination, oromotor skills, and cerebellar function than did those with Down syndrome. The neurologic distinctions between these 2 groups may reflect an underlying, as yet undefined, metabolic defect in Williams syndrome. |
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Authors:
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D A Trauner; U Bellugi; C Chase |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatric neurology Volume: 5 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 1989 May-Jun |
Date Detail:
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Created Date: 1989-08-17 Completed Date: 1989-08-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 166-8 Citation Subset: IM |
Affiliation:
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Department of Neurosciences, University of California School of Medicine, La Jolla. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain Diseases / complications, physiopathology* Down Syndrome / complications, physiopathology* Humans Mental Retardation / complications, physiopathology* Muscle Hypotonia / etiology Syndrome |
| Grant Support | |
ID/Acronym/Agency:
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NS22343/NS/NINDS NIH HHS |
| Comments/Corrections | |
Comment In:
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Pediatr Neurol. 1993 Sep-Oct;9(5):414
[PMID:
8292223
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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