Document Detail


Neurologic dysfunctions caused by a molecular clone of feline immunodeficiency virus, FIV-PPR.
MedLine Citation:
PMID:  8972420     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
FIV is a lentivirus of domestic cats that causes a spectrum of diseases that is remarkably similar to the clinical syndrome produced by HIV infection in people. Both HIV and FIV has been shown to cause neurologic dysfunction. Specific Pathogen-Free (SPF) cats were placed into one of three groups: FIV-PPR infected; DU-FIV-PPR (a dUTPase mutant of the FIV-PPR clone) infected; or an age-matched control group. In both infected groups, the general clinical signs of infection included lymphadenopathy, oral ulcerations, rough hair coat, and conjuntivitis. Specific neurological changes in the FIV-PPR infected cats included hind limb paresis; delayed righting and pupillary reflexes; behavioral changes; delayed visual and auditory evoked potentials; decreased spinal and peripheral nerve conduction velocities; and marked alterations in sleep patterns. Most of these changes were also observed in the DU-FIV-PPR infected cats. However, these cats tended to have a slightly less severe disease. In this study, we have demonstrated that an infectious molecular clone of FIV closely parallels the disease course of wild type FIV-infected cats. By using a knockout gene mutant of this clone, we were able to demonstrate that the dUTPase gene is not essential for neuropathogenesis. Further use of the FIV-PPR clone should prove useful in determining the essential viral elements that are important in the neuropathogenesis of lentiviral infections.
Authors:
T R Phillips; O Prospero-Garcia; D W Wheeler; P C Wagaman; D L Lerner; H S Fox; L R Whalen; F E Bloom; J H Elder; S J Henriksen
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurovirology     Volume:  2     ISSN:  1355-0284     ISO Abbreviation:  J. Neurovirol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-17     Completed Date:  1997-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9508123     Medline TA:  J Neurovirol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  388-96     Citation Subset:  IM; X    
Affiliation:
Neuropharmacology, Scripps Research Institute, La Jolla California 92037, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Cloning, Molecular
Electroencephalography
Evoked Potentials, Auditory, Brain Stem
Evoked Potentials, Somatosensory
Feline Acquired Immunodeficiency Syndrome / physiopathology*,  virology
Genes, Viral / genetics
Immunodeficiency Virus, Feline / genetics*,  pathogenicity
Mutagenesis / physiology
Nervous System Diseases / physiopathology,  virology*
Neural Conduction / physiology
Peripheral Nerves / enzymology,  physiopathology,  virology
Pyrophosphatases / genetics,  metabolism
Sleep / physiology
Spinal Cord / enzymology,  physiopathology,  virology
Virulence
Grant Support
ID/Acronym/Agency:
AI25825/AI/NIAID NIH HHS; MH47680/MH/NIMH NIH HHS; RR10712/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
EC 3.6.1.-/Pyrophosphatases; EC 3.6.1.-/uridine triphosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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