Document Detail

Neurologic birth defects after prenatal exposure to antiepileptic drugs.
MedLine Citation:
PMID:  19087116     Owner:  NLM     Status:  MEDLINE    
Maternal epilepsy has a potential for fetal injury, either antiepileptic drug (AED)--induced or as a consequence of seizures per se. The intent of this article is to explore this relationship, discussing similar patterns of malformations seen with AEDs or different disease exposure during pregnancy, and the potential role of gap junctional intercellular communication in abnormal morphogenesis.
Daniela Uziel; Renato Rozental
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Epilepsia     Volume:  49 Suppl 9     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-17     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-42     Citation Subset:  IM    
Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
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MeSH Terms
Abnormalities, Drug-Induced / etiology*,  pathology
Anticonvulsants / adverse effects*
Brain / abnormalities*,  embryology
Prenatal Exposure Delayed Effects / pathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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