| Neurologic consequences of the immune reconstitution inflammatory syndrome (IRIS). | |
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MedLine Citation:
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PMID: 20697980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although major advancements have been made in the treatment of HIV infection, graft-versus-host reactions, and autoimmune diseases, an unexpected consequence of treatment has been the emergence of a devastating inflammatory syndrome, termed the immune reconstitution inflammatory syndrome (IRIS). The pathophysiology of the syndrome is poorly understood, and the syndrome poses unique challenges for diagnosis and treatment. We have reviewed the neurologic manifestations of IRIS in the context of HIV infection as well as in the setting of treatment of autoimmune diseases such as multiple sclerosis, in which compartmental immune suppression may occur without an obvious underlying immune suppression. The purpose of this review is to identify common themes that may assist in the diagnosis and management of these IRIS syndromes. |
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Authors:
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Micheline McCarthy; Avindra Nath |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current neurology and neuroscience reports Volume: 10 ISSN: 1534-6293 ISO Abbreviation: Curr Neurol Neurosci Rep Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2011-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100931790 Medline TA: Curr Neurol Neurosci Rep Country: United States |
Other Details:
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Languages: eng Pagination: 467-75 Citation Subset: IM |
Affiliation:
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Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33125, USA. mmccarth@med.miami.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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therapeutic use* HIV Infections / complications, diagnosis, drug therapy* HIV-1 Humans Immune Reconstitution Inflammatory Syndrome / complications, diagnosis*, drug therapy* Nervous System Diseases / complications, diagnosis*, drug therapy* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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