Document Detail


Neuroleptic malignant syndrome under treatment with antidepressants? A critical review.
MedLine Citation:
PMID:  9840369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuroleptic malignant syndrome (NMS) is a rare complication of treatment with neuroleptics. The pathophysiology is not fully known. A dopaminergic transmission block in the basal ganglia and hypothalamus is thought to be the pathophysiological mechanism of NMS. Several cases of NMS have been reported, precipitated by medication without a direct effect on the dopaminergic system. This Medline analysis concerns 23 cases of antidepressant-induced NMS reported in the literature with the differing pathophysiological hypotheses on the precipitation of NMS. The results indicate no hard evidence of an antidepressant-evoked NMS. However, various hypotheses assuming an disturbed balance of the dopaminergic and non-dopaminergic system may be relevant in animal studies, but are without clinically relevant proof presently. An antidepressant-induced NMS is a very rare complication on the basis of pretreatment with neuroleptics causing chronic dopamine blockade and elevated plasma level of neuroleptics due to comedicated antidepressants.
Authors:
H J Assion; F Heinemann; G Laux
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European archives of psychiatry and clinical neuroscience     Volume:  248     ISSN:  0940-1334     ISO Abbreviation:  Eur Arch Psychiatry Clin Neurosci     Publication Date:  1998  
Date Detail:
Created Date:  1999-02-26     Completed Date:  1999-02-26     Revised Date:  2009-05-11    
Medline Journal Info:
Nlm Unique ID:  9103030     Medline TA:  Eur Arch Psychiatry Clin Neurosci     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  231-9     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Bochum, Germany.
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MeSH Terms
Descriptor/Qualifier:
Antidepressive Agents / adverse effects*
Female
Humans
Male
Neuroleptic Malignant Syndrome / etiology*,  physiopathology
Chemical
Reg. No./Substance:
0/Antidepressive Agents

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