Document Detail

Neuroleptic malignant syndrome: a study of CSF monoamine metabolism.
MedLine Citation:
PMID:  1689186     Owner:  NLM     Status:  MEDLINE    
In 8 cases of typical neuroleptic malignant syndrome (NMS), homovanillic acid (HVA), 5-hydroxyindole acetic acid (5-HIAA), noradrenaline (NA), and 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) levels in the cerebrospinal fluid (CSF) were assayed during both the active phase of NMS and after recovery. Compared with levels in normal control subjects the levels of HVA were significantly lower in patients with active NMS. This finding supports the central dopamine blockade theory of NMS pathophysiology. In addition, the levels of HVA were significantly decreased after recovery, suggesting that there may be a decreased dopamine metabolism in patients susceptible to NMS. The levels of 5-HIAA in patients with active NMS and after recovery were also significantly lower than those in normal control group, suggesting a relationship between the development of NMS and a disturbance of serotonin metabolism. The levels of NA in patients with active NMS were significantly higher than in normal subjects, and were within normal range after recovery. The levels of MHPG had a tendency to increase in patients with active NMS, compared with levels during recovery. These findings are a result of increased sympathetic nervous system activity in patients with active NMS; however, they are also observed in other disorders and may well reflect the physical stress caused by NMS.
K Nisijima; T Ishiguro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  27     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-28     Completed Date:  1990-03-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  280-8     Citation Subset:  IM    
Department of Psychiatry, Jichii Medical School, Tochigi-Ken, Japan.
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MeSH Terms
Biogenic Monoamines / cerebrospinal fluid*
Bipolar Disorder / cerebrospinal fluid
Depressive Disorder / cerebrospinal fluid
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Mental Retardation / cerebrospinal fluid
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Middle Aged
Neuroleptic Malignant Syndrome / cerebrospinal fluid*,  diagnosis
Norepinephrine / cerebrospinal fluid
Schizophrenia / cerebrospinal fluid
Reg. No./Substance:
0/Biogenic Monoamines; 306-08-1/Homovanillic Acid; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

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