Document Detail

Neuroleptic malignant syndrome-like, or--dopaminergic malignant syndrome--due to levodopa therapy withdrawal. Clinical features in 11 patients.
MedLine Citation:
PMID:  12573874     Owner:  NLM     Status:  MEDLINE    
A clinical picture named neuroleptic malignant-like syndrome has been described in patients with Parkinson's disease (PD) who suddenly stop their L-dopa treatment. The sudden withdrawal of the drug is deemed to lead to an acute deficiency stage in a patient who has an iatrogenic increase of dopaminergic transmission. We present a series of 11 patients with PD with an average age of 72.09 years, a mean disease duration of 9.45 years who developed this problem after a 92.72 h latency period. If patients with PD develop severe rigidity, stupor and hyperthermia, L-dopa withdrawal should be suspected and the dopaminergic drug restarted as soon as possible.
Marcos Serrano-Dueñas
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  9     ISSN:  1353-8020     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-02-07     Completed Date:  2003-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  175-8     Citation Subset:  IM    
Servicio de Neurología del Hospital Carlos Andrade Marín and Facultad de Medicina de la Pontificia, Universidad Catolica del Ecuador, PO Box 17-03-1694, Quito, Ecuador.
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MeSH Terms
Analysis of Variance
Diagnosis, Differential
Levodopa / adverse effects*
Middle Aged
Neuroleptic Malignant Syndrome / diagnosis*,  drug therapy,  physiopathology
Parkinson Disease / drug therapy,  physiopathology
Substance Withdrawal Syndrome / diagnosis*,  drug therapy,  physiopathology
Reg. No./Substance:

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