| Neuroleptic malignant syndrome and clozapine. | |
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MedLine Citation:
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PMID: 8102300 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clozapine is an atypical neuroleptic drug that was initially thought not to cause neuroleptic malignant syndrome (NMS). We report a case of NMS associated with clozapine as a single agent that developed in a patient with no prior history of NMS. In contrast to other reported cases of NMS with clozapine monotherapy in which rigidity was reported to be absent, our patient had classic NMS with lead-pipe rigidity. NMS should be included in the differential diagnosis of a febrile patient with a history of any neuroleptic treatment, including clozapine. |
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Authors:
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S Reddig; A M Minnema; R Tandon |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists Volume: 5 ISSN: 1040-1237 ISO Abbreviation: Ann Clin Psychiatry Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-09-16 Completed Date: 1993-09-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8911021 Medline TA: Ann Clin Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 25-7 Citation Subset: IM |
Affiliation:
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University of Michigan Medical Center, Ann Arbor 48109-0120. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / adverse effects Bromocriptine / therapeutic use Clozapine / administration & dosage, adverse effects*, therapeutic use Dantrolene / therapeutic use Diagnosis, Differential Fever / chemically induced, diagnosis Humans Male Muscle Rigidity / chemically induced, diagnosis Neuroleptic Malignant Syndrome / diagnosis*, drug therapy, etiology Schizophrenia / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 25614-03-3/Bromocriptine; 5786-21-0/Clozapine; 7261-97-4/Dantrolene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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