Document Detail

Neuroleptic malignant syndrome and clozapine.
MedLine Citation:
PMID:  8102300     Owner:  NLM     Status:  MEDLINE    
Clozapine is an atypical neuroleptic drug that was initially thought not to cause neuroleptic malignant syndrome (NMS). We report a case of NMS associated with clozapine as a single agent that developed in a patient with no prior history of NMS. In contrast to other reported cases of NMS with clozapine monotherapy in which rigidity was reported to be absent, our patient had classic NMS with lead-pipe rigidity. NMS should be included in the differential diagnosis of a febrile patient with a history of any neuroleptic treatment, including clozapine.
S Reddig; A M Minnema; R Tandon
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists     Volume:  5     ISSN:  1040-1237     ISO Abbreviation:  Ann Clin Psychiatry     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-09-16     Completed Date:  1993-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8911021     Medline TA:  Ann Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  25-7     Citation Subset:  IM    
University of Michigan Medical Center, Ann Arbor 48109-0120.
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MeSH Terms
Antipsychotic Agents / adverse effects
Bromocriptine / therapeutic use
Clozapine / administration & dosage,  adverse effects*,  therapeutic use
Dantrolene / therapeutic use
Diagnosis, Differential
Fever / chemically induced,  diagnosis
Muscle Rigidity / chemically induced,  diagnosis
Neuroleptic Malignant Syndrome / diagnosis*,  drug therapy,  etiology
Schizophrenia / drug therapy*
Reg. No./Substance:
0/Antipsychotic Agents; 25614-03-3/Bromocriptine; 5786-21-0/Clozapine; 7261-97-4/Dantrolene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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