Document Detail

Neuroleptic malignant syndrome associated with atypical antipsychotics in pediatric patients: a review of published cases.
MedLine Citation:
PMID:  18572981     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To retrospectively examine published cases of neuroleptic malignant syndrome (NMS) in patients aged 18 and below who had been treated with atypical antipsychotics (clozapine, risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole).
DATA SOURCES: Information was collected via MEDLINE searches in February 2006 and May 2007. The term neuroleptic malignant syndrome was used and cross-referenced with individual atypical antipsychotics. The authors also contacted (by telephone and in writing) pharmaceutical companies that produce and market atypical antipsychotics for any data on NMS.
STUDY SELECTION: Twenty case reports (written in English only and published from 1991-2007) were identified and reviewed. These publications all described symptoms of NMS in patients aged 18 or younger who had been treated with atypical antipsychotics.
DATA EXTRACTION: Data were reviewed and compared with 3 diagnostic criteria (DSM-IV-TR, Levenson's, and Caroff and Mann's) for NMS. Interventions and outcomes were also reviewed.
DATA SYNTHESIS: Twenty case reports were identified and presented with a descriptive approach. Sixteen cases met criteria for NMS, with at least 1 of the diagnostic sets utilized. The majority of cases involved male subjects. All patients recovered.
CONCLUSIONS: Young patients can develop NMS during treatment with atypical antipsychotics. Symptoms of this disorder are consistent with those described in adults. Although NMS is rare in this population, clinicians should maintain a high index of suspicion. Appropriate caution in treating children and adolescents with any antipsychotic is warranted.
Paul E Croarkin; Graham J Emslie; Taryn L Mayes
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  69     ISSN:  1555-2101     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-08     Completed Date:  2008-09-09     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1157-65     Citation Subset:  IM    
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
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MeSH Terms
Antipsychotic Agents / adverse effects*
Benzodiazepines / adverse effects
Bipolar Disorder / drug therapy*
Child, Preschool
Clozapine / adverse effects
Dibenzothiazepines / adverse effects
Neuroleptic Malignant Syndrome / diagnosis,  etiology*
Piperazines / adverse effects
Quinolones / adverse effects
Retrospective Studies
Risperidone / adverse effects
Thiazoles / adverse effects
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/Piperazines; 0/Quinolones; 0/Thiazoles; 106266-06-2/Risperidone; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 5786-21-0/Clozapine; 6UKA5VEJ6X/ziprasidone; 82VFR53I78/aripiprazole; BGL0JSY5SI/quetiapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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