Document Detail

Neuroleptic-like anorexia produced by an extra-cerebral DA antagonist.
MedLine Citation:
PMID:  6138129     Owner:  NLM     Status:  MEDLINE    
The effects of the DA receptor antagonists metoclopramide and pimozide on food and water intake in male Sprague Dawley rats were compared to those of domperidone, which does not cross the blood-brain barrier, in an attempt to determine whether any extracerebral DA receptors participate in neuroleptic induced anorexia. While metoclopramide caused only minor changes in food and water intake at the doses employed both pimozide and domperidone caused a significant reduction in food intake and water consumption 1 hr and 4 hr after injection during a 4 hr intake test. These results support the hypothesis that the nigrostriatal system may not be the system principally involved in the neuroleptic induced anorexia which occurs after the administration of these drugs.
G L Willis; G C Smith; P C Kinchington
Related Documents :
23400619 - Athletes' opinions of food provision at the 2010 delhi commonwealth games: the influenc...
23252829 - The impact of instrumental feeding on children's responses to taste exposure.
6504949 - Opiate antagonists stereoselectively attenuate the consumption of food but not of water...
8856829 - Naloxone effects on sucrose-motivated behavior.
21888589 - Factors influencing the food choices and eating habits of restaurant chefs in northern ...
25382639 - Expression of monellin in a food-grade delivery system in saccharomyces cerevisiae.
20409359 - Effects of a school-based intervention on adherence of 7-9-year-olds to food-based diet...
23339029 - Benefits of using algae as natural sources of functional ingredients.
11924549 - Impact of wildfires on the air quality of mexico city, 1992-1999.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research bulletin     Volume:  11     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anorexia / chemically induced,  physiopathology*
Antipsychotic Agents
Brain / physiopathology
Domperidone / pharmacology*
Drinking Behavior / drug effects*
Eating Disorders / physiopathology*
Feeding Behavior / drug effects*
Metoclopramide / pharmacology*
Pimozide / pharmacology*
Rats, Inbred Strains
Receptors, Dopamine / drug effects*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Receptors, Dopamine; 2062-78-4/Pimozide; 364-62-5/Metoclopramide; 57808-66-9/Domperidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Aminergic blockade modulates long-term potentiation in the dentate gyrus of freely moving rats.
Next Document:  Plasma gonadotropin, prolactin levels and hypothalamic tyrosine hydroxylase activity following intra...