Document Detail

Neuroleptic-like anorexia produced by an extra-cerebral DA antagonist.
MedLine Citation:
PMID:  6138129     Owner:  NLM     Status:  MEDLINE    
The effects of the DA receptor antagonists metoclopramide and pimozide on food and water intake in male Sprague Dawley rats were compared to those of domperidone, which does not cross the blood-brain barrier, in an attempt to determine whether any extracerebral DA receptors participate in neuroleptic induced anorexia. While metoclopramide caused only minor changes in food and water intake at the doses employed both pimozide and domperidone caused a significant reduction in food intake and water consumption 1 hr and 4 hr after injection during a 4 hr intake test. These results support the hypothesis that the nigrostriatal system may not be the system principally involved in the neuroleptic induced anorexia which occurs after the administration of these drugs.
G L Willis; G C Smith; P C Kinchington
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research bulletin     Volume:  11     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
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MeSH Terms
Anorexia / chemically induced,  physiopathology*
Antipsychotic Agents
Brain / physiopathology
Domperidone / pharmacology*
Drinking Behavior / drug effects*
Eating Disorders / physiopathology*
Feeding Behavior / drug effects*
Metoclopramide / pharmacology*
Pimozide / pharmacology*
Rats, Inbred Strains
Receptors, Dopamine / drug effects*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Receptors, Dopamine; 2062-78-4/Pimozide; 364-62-5/Metoclopramide; 57808-66-9/Domperidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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