| Neuroleptic-like anorexia produced by an extra-cerebral DA antagonist. | |
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MedLine Citation:
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PMID: 6138129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of the DA receptor antagonists metoclopramide and pimozide on food and water intake in male Sprague Dawley rats were compared to those of domperidone, which does not cross the blood-brain barrier, in an attempt to determine whether any extracerebral DA receptors participate in neuroleptic induced anorexia. While metoclopramide caused only minor changes in food and water intake at the doses employed both pimozide and domperidone caused a significant reduction in food intake and water consumption 1 hr and 4 hr after injection during a 4 hr intake test. These results support the hypothesis that the nigrostriatal system may not be the system principally involved in the neuroleptic induced anorexia which occurs after the administration of these drugs. |
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Authors:
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G L Willis; G C Smith; P C Kinchington |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research bulletin Volume: 11 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1983 Jul |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 21-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anorexia / chemically induced, physiopathology* Antipsychotic Agents Brain / physiopathology Domperidone / pharmacology* Drinking Behavior / drug effects* Eating Disorders / physiopathology* Feeding Behavior / drug effects* Humans Male Metoclopramide / pharmacology* Pimozide / pharmacology* Rats Rats, Inbred Strains Receptors, Dopamine / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Receptors, Dopamine; 2062-78-4/Pimozide; 364-62-5/Metoclopramide; 57808-66-9/Domperidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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