| Neuroleptic-induced catatonia after abrupt withdrawal of amantadine during neuroleptic therapy. | |
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MedLine Citation:
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PMID: 2877444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Catatonic reactions to high-potency neuroleptic drugs have been described in the literature. Our patient developed neuroleptic-induced catatonia (NIC) after abrupt withdrawal of amantadine, a dopaminergic agent that has been implicated in neuroleptic malignant syndrome (NMS) on its discontinuation. This case report adds support to the hypothesis that NIC and NMS are 2 syndromes on a continuum of dopamine blockade, each of which may be treated with or uncovered by amantadine therapy. |
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Authors:
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C S Brown; A K Wittkowsky; S G Bryant |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pharmacotherapy Volume: 6 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 1986 Jul-Aug |
Date Detail:
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Created Date: 1986-11-25 Completed Date: 1986-11-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 193-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Amantadine / adverse effects*, therapeutic use Antipsychotic Agents / adverse effects*, therapeutic use Bipolar Disorder / drug therapy Catatonia / chemically induced* Female Humans Parkinson Disease, Secondary / chemically induced Substance Withdrawal Syndrome* Thiothixene / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 5591-45-7/Thiothixene; 768-94-5/Amantadine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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