Document Detail

Neuroleptic and anticholinergic drug use in Chinese patients with schizophrenia resident in a state psychiatric hospital in Singapore.
MedLine Citation:
PMID:  11127630     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to survey the prescribing pattern in Chinese patients with chronic schizophrenia in a state mental hospital in Singapore, and to compare our findings with those of surveys of Chinese patients in other countries. METHOD: We surveyed the use of neuroleptic and anticholinergic agents among Chinese patients with chronic schizophrenia (n = 534) in a state mental hospital in Singapore. RESULTS: Fifty-nine per cent of the patients received two or more neuroleptics (median daily dose of 400 mg chlorpromazine equivalents, range 50-2875 mg). There were no differences in gender distribution between those prescribed multiple neuroleptics as against an older group of those receiving none or only one neuroleptic medication. Sixty-six per cent of the patients were receiving depot neuroleptics, with more than half of these subjects also receiving additional oral neuroleptics. Patients who were prescribed multiple neuroleptics received significantly higher total doses than those receiving just one neuroleptic. Only 1% of patients were prescribed an atypical neuroleptic. Sixty-five per cent of patients were prescribed an anticholinergic agent. Those prescribed anticholinergic agents were younger, in receipt of higher doses of neuroleptic medications and had lower Simpson-Angus scores for extrapyramidal side-effects. CONCLUSIONS: The pervasive use of multiple typical neuroleptics, marked underutilisation of atypical neuroleptics, and the lack of anticholinergic medication in patients who might benefit from such treatment are issues of substantial concern, warranting action in both psychiatry practice and mental health policy.
S A Chong; P Sachdev; R Mahendran; H C Chua
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australian and New Zealand journal of psychiatry     Volume:  34     ISSN:  0004-8674     ISO Abbreviation:  Aust N Z J Psychiatry     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-02-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0111052     Medline TA:  Aust N Z J Psychiatry     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  988-91     Citation Subset:  IM    
Department of Adult Psychiatry, Woodbridge Hospital and Institute of Mental Health, Singapore.
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MeSH Terms
Antipsychotic Agents / adverse effects,  therapeutic use*
Asian Continental Ancestry Group*
Cholinergic Antagonists / adverse effects,  therapeutic use*
Chronic Disease
Drug Utilization
Hospitals, Psychiatric
Hospitals, State
Middle Aged
Schizophrenia / drug therapy*,  ethnology
Reg. No./Substance:
0/Antipsychotic Agents; 0/Cholinergic Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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