Document Detail

Neuroleptic Malignant Syndrome Induced by Combination Therapy with Tetrabenazine and Tiapride in a Japanese Patient with Huntington's Disease at the Terminal Stage of Recurrent Breast Cancer.
MedLine Citation:
PMID:  24881749     Owner:  NLM     Status:  In-Data-Review    
We herein describe the case of an 81-year-old Japanese woman with neuroleptic malignant syndrome that occurred 36 days after the initiation of combination therapy with tiapride (75 mg/day) and tetrabenazine (12.5 mg/day) for Huntington's disease. The patient had been treated with tiapride or tetrabenazine alone without any adverse effects before the administration of the combination therapy. She also had advanced breast cancer when the combination therapy was initiated. To the best of our knowledge, the occurrence of neuroleptic malignant syndrome due to combination therapy with tetrabenazine and tiapride has not been previously reported. Tetrabenazine should be administered very carefully in combination with other neuroleptic drugs, particularly in patients with a worsening general condition.
Ichiro Nozaki; Yutaka Furukawa; Yuko Kato-Motozaki; Tokuhei Ikeda; Atsuro Tagami; Kazuya Takahashi; Chiho Ishida; Kiyonobu Komai
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Publication Detail:
Type:  Journal Article     Date:  2014-06-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  53     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2014  
Date Detail:
Created Date:  2014-06-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1201-4     Citation Subset:  IM    
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