Document Detail

Neurokinin A induces expression of the c-fos, c-jun, and c-myc genes in rat smooth muscle cells.
MedLine Citation:
PMID:  2176599     Owner:  NLM     Status:  MEDLINE    
Neurokinin A, a member of the tachykinin family of neuropeptides, has been identified as a mitogen for cultured smooth muscle cells. Tachykinin-induced DNA synthesis has previously been shown to be mediated by a receptor-specific mechanism and to correlate with accumulation of phosphatidylinositol 4,5-bisphosphate breakdown products. In the present experiments, we have studied intracellular pH and expression of the proto-oncogenes c-myc, c-jun and c-fos in smooth muscle cells exposed to mitogenic concentrations of neurokinin A. Growth-arrested smooth muscle cells stimulated with neurokinin A responded with an amiloride-sensitive intracellular alkalinization, indicating Na+/H+ antiport activation. c-myc and c-jun mRNA expression was only slightly elevated by neurokinin A, while c-fos expression underwent a more pronounced increase. Maximal levels of c-fos transcripts were found after 15 min and 30 min following neurokinin A stimulation. The results demonstrate that neuropeptides may influence proto-oncogene expression in smooth muscle cells and suggest a mechanism by which peripheral neurons may modulate differentiation and growth of these cells.
A Hultgårdh-Nilsson; S H Larsson; P Jin; T Sejersen; N R Ringertz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of biochemistry / FEBS     Volume:  194     ISSN:  0014-2956     ISO Abbreviation:  Eur. J. Biochem.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-02-20     Completed Date:  1991-02-20     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  0107600     Medline TA:  Eur J Biochem     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  527-32     Citation Subset:  IM    
Department of Medical Cell Genetics, Medical Nobel Institute, Stockholm, Sweden.
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MeSH Terms
Amiloride / pharmacology
Blotting, Northern
DNA / biosynthesis,  drug effects
DNA-Binding Proteins / genetics*
Gene Expression Regulation / drug effects*
Hydrogen-Ion Concentration
Muscle, Smooth / cytology,  drug effects*
Neurokinin A / pharmacology*
Nisoldipine / pharmacology
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins c-fos
Proto-Oncogene Proteins c-jun
Proto-Oncogene Proteins c-myc / genetics*
Proto-Oncogenes / drug effects*
Rats, Inbred Strains
Sulfonamides / pharmacology
Transcription Factors / genetics*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Proto-Oncogene Proteins c-myc; 0/Sulfonamides; 0/Transcription Factors; 2609-46-3/Amiloride; 63675-72-9/Nisoldipine; 65595-90-6/W 7; 86933-74-6/Neurokinin A; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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