| Neurokinin-1 receptor (NK1-R) expression in the brains of SIV-infected rhesus macaques: implications for substance P in NK1-R immune cell trafficking into the CNS. | |
| | |
MedLine Citation:
|
PMID: 20671267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent studies suggest a link between neuropsychiatric disorders and HIV/SIV infection. Most evidence indicates that monocytes/macrophages are the primary cell type infected within the CNS and that they contribute to CNS inflammation and neurological disease. Substance P (SP), a pleotropic neuropeptide implicated in inflammation, depression, and immune modulation via interaction with its cognate receptor, the neurokinin 1 receptor (NK1-R), is produced by monocyte/macrophages. While the presence of NK1-R on neurons is well known, its role on cells of the immune system such as monocyte/macrophages is just beginning to emerge. Therefore, we have examined the expression of SP and NK1-R and their relationship to SIV/HIV encephalitis (SIVE/HIVE) lesions and SIV-infected cells. These studies demonstrated intense expression of SP and NK1-R in SIVE lesions, with macrophages being the principal cell expressing NK1-R. Interestingly, all of the SIV-infected macrophages expressed NK1-R. Additionally, we examined the functional role of SP as a proinflammatory mediator of monocyte activation and chemotaxis. These studies demonstrated that treatment of monocytes with SP elicited changes in cell-surface expression for CCR5 and NK1-R in a dose-dependent manner. Moreover, pretreatment with SP enhanced both SP- and CCL5-mediated chemotaxis. All of these findings suggest that SP and NK1-R are important in SIV infection of macrophages and the development of SIVE lesions. |
| | |
Authors:
|
Heather Vinet-Oliphant; Xavier Alvarez; Elizabeth Buza; Juan T Borda; Mahesh Mohan; Pyone P Aye; Florin Tuluc; Steven D Douglas; Andrew A Lackner |
Related Documents
:
|
16765097 - Perturbations in the catfish immune responses by arsenic: organ and cell specific effects. 12865897 - Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupt... 11339507 - In vitro melatonin treatment enhances cell-mediated immune function in male prairie vol... 8107527 - Effects of cgrp in different models of mouse ear inflammation. 21303257 - Knockdown of akt1 promotes akt2 upregulation and resistance to oxidative-stress-induced... 18672287 - The complement system in the peripheral nerve: friend or foe? |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-29 |
Journal Detail:
|
Title: The American journal of pathology Volume: 177 ISSN: 1525-2191 ISO Abbreviation: Am. J. Pathol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-31 Completed Date: 2010-12-13 Revised Date: 2011-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 1286-97 Citation Subset: AIM; IM |
Affiliation:
|
Tulane National Primate Research Center, Division of Comparative Pathology, Covington, LA 70433, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Astrocytes / immunology, metabolism, virology Brain / immunology, metabolism*, virology Cell Movement Cells, Cultured Flow Cytometry Immunohistochemistry Macaca mulatta Macrophages / immunology, metabolism, virology Microscopy, Confocal Neurons / immunology, metabolism, virology Receptors, Neurokinin-1 / immunology, metabolism* Simian Acquired Immunodeficiency Syndrome / immunology, metabolism*, virology Simian immunodeficiency virus / immunology* Substance P / immunology, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
MH076388/MH/NIMH NIH HHS; NS30769/NS/NINDS NIH HHS; RR000164/RR/NCRR NIH HHS; RR016930/RR/NCRR NIH HHS; RR018397/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Neurokinin-1; 33507-63-0/Substance P |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carbo...
Next Document: Engineered zinc finger nuclease-mediated homologous recombination of the human rhodopsin gene.