Document Detail

Neuroinflammation: beneficial and detrimental effects after traumatic brain injury.
MedLine Citation:
PMID:  23296919     Owner:  NLM     Status:  Publisher    
Traumatic brain injury (TBI) is the major cause of death and severe disability in young adults and infants worldwide and many survivors also have mild to moderate neurological deficits which impair their lives. This review highlights the primary and secondary lesions constituting craniocerebral trauma and the main elements of neuroinflammation, one of the most important secondary events evolving after the initial traumatic insult. Neuroinflammation has dual and opposing roles in outcome after TBI, being both beneficial and harmful, its effects often differing between the acute and more delayed phases after injury. Since each patient with TBI has a unique and complex pattern of cerebral damage, developing pharmacological intervention strategies targeted at the multiple cellular and molecular events in the neuroinflammatory cascade is difficult. While there have been very few successful outcomes to date in human clinical trials of drugs developed to treat TBI in general, those that have been devised to modulate neuroinflammation are discussed.
J W Finnie
Related Documents :
23563449 - Neonatal hypothermia in sub-saharan africa: a review.
23031159 - The presence of black vultures at the calving sites and its effects on cows' and calves...
17883879 - Malaria-related mortality based on verbal autopsy in an area of low endemicity in a pre...
7596209 - Effects of the threat of medical malpractice litigation and other factors on birth outc...
17128339 - Causes of stillbirths and early neonatal deaths: data from 7993 pregnancies in six deve...
23007949 - Therapeutic hypothermia for neonatal encephalopathy.
1923189 - Ultrasound surveillance of the cervix in twin gestations: management of cervical incomp...
18952629 - Plasma ip-10 as a predictor of serious bacterial infection in infants less than 4 month...
14690209 - Foal-related risk factors associated with development of rhodococcus equi pneumonia on ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  Inflammopharmacology     Volume:  -     ISSN:  1568-5608     ISO Abbreviation:  Inflammopharmacology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112626     Medline TA:  Inflammopharmacology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
SA Pathology, Hanson Institute Centre for Neurological Diseases and Schools of Medical and Veterinary Sciences, University of Adelaide, PO Box 14, Rundle Mall, Adelaide, SA, 5000, Australia,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Photosynthetic based algal-bacterial combined treatment of mixtures of organic pollutants and CO(2) ...
Next Document:  An integrative variant analysis pipeline for accurate genotype/haplotype inference in population NGS...