Document Detail

Neuroimmunoendocrine circuitry of the 'brain-skin connection'.
MedLine Citation:
PMID:  16269267     Owner:  NLM     Status:  MEDLINE    
The skin offers an ideally suited, clinically relevant model for studying the crossroads between peripheral and systemic responses to stress. A 'brain-skin connection' with local neuroimmunoendocrine circuitry underlies the pathogenesis of allergic and inflammatory skin diseases, triggered or aggravated by stress. In stressed mice, corticotropin-releasing hormone, nerve growth factor, neurotensin, substance P and mast cells are recruited hierarchically to induce neurogenic skin inflammation, which inhibits hair growth. The hair follicle is both a target and a source for immunomodulatory stress mediators, and has an equivalent of the hypothalamus-pituitary-adrenal axis. Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention.
Ralf Paus; Theoharis C Theoharides; Petra Clara Arck
Related Documents :
6718297 - Effect of selection for delayed amelanosis on immune response in chickens. 2. cell-medi...
6982907 - Immune modulation by epidermal cell products: possible role of etaf in inflammatory and...
14632207 - High ultraviolet a protection affords greater immune protection confirming that ultravi...
15989537 - Emerging drugs in psoriasis.
11325677 - Selective sequestration of cytokine-producing monocytes during hemodialysis treatment.
24893117 - Diminazene aceturate (berenil), a new use for an old compound?
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2005-11-02
Journal Detail:
Title:  Trends in immunology     Volume:  27     ISSN:  1471-4906     ISO Abbreviation:  Trends Immunol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-11-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100966032     Medline TA:  Trends Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  32-9     Citation Subset:  IM    
Department of Dermatology, University Hospital Schleswig-Holstein, Campus Lübeck, University of Lübeck, D-23538 Lübeck, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / immunology*,  metabolism*
Hair Follicle / cytology,  immunology,  metabolism
Neurons / immunology*,  secretion*
Neurosecretory Systems
Skin / immunology*,  metabolism*
Stress, Physiological / immunology,  metabolism,  psychology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Geographic and ethnic differences in frequencies of two polymorphisms (D/N394 and L/I272) of the par...
Next Document:  Antioxidant enzymes in ringed seal tissues: potential protection against dive-associated ischemia/re...