Document Detail


Neuroimmunoendocrine circuitry of the 'brain-skin connection'.
MedLine Citation:
PMID:  16269267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The skin offers an ideally suited, clinically relevant model for studying the crossroads between peripheral and systemic responses to stress. A 'brain-skin connection' with local neuroimmunoendocrine circuitry underlies the pathogenesis of allergic and inflammatory skin diseases, triggered or aggravated by stress. In stressed mice, corticotropin-releasing hormone, nerve growth factor, neurotensin, substance P and mast cells are recruited hierarchically to induce neurogenic skin inflammation, which inhibits hair growth. The hair follicle is both a target and a source for immunomodulatory stress mediators, and has an equivalent of the hypothalamus-pituitary-adrenal axis. Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention.
Authors:
Ralf Paus; Theoharis C Theoharides; Petra Clara Arck
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2005-11-02
Journal Detail:
Title:  Trends in immunology     Volume:  27     ISSN:  1471-4906     ISO Abbreviation:  Trends Immunol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-11-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100966032     Medline TA:  Trends Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  32-9     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University Hospital Schleswig-Holstein, Campus Lübeck, University of Lübeck, D-23538 Lübeck, Germany. ralf.paus@uk-sh.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / immunology*,  metabolism*
Hair Follicle / cytology,  immunology,  metabolism
Humans
Neurons / immunology*,  secretion*
Neurosecretory Systems
Skin / immunology*,  metabolism*
Stress, Physiological / immunology,  metabolism,  psychology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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