Document Detail


Neuroimmune mechanisms in fetal alcohol spectrum disorder.
MedLine Citation:
PMID:  22623427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal alcohol spectrum disorder (FASD) is a major health concern worldwide and results from maternal consumption of alcohol during pregnancy. It produces tremendous individual, social, and economic losses. This review will first summarize the structural, functional, and behavior changes seen in FASD. The development of the neuroimmune system will be then be described with particular emphasis on the role of microglial cells in the normal regulation of homeostatic function in the central nervous system (CNS) including synaptic transmission. The impact of alcohol on the neuroimmune system in the developing CNS will be discussed in the context of several key immune molecules and signaling pathways involved in neuroimmune mechanisms that contribute to FASD. This review concludes with a summary of the development of early therapeutic approaches utilizing immunosuppressive drugs to target alcohol-induced pathologies. The significant role played by neuroimmune mechanisms in alcohol addiction and pathology provides a focus for future research aimed at understanding and treating the consequences of FASD.
Authors:
Cynthia J M Kane; Kevin D Phelan; Paul D Drew
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-09-01
Journal Detail:
Title:  Developmental neurobiology     Volume:  72     ISSN:  1932-846X     ISO Abbreviation:  Dev Neurobiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-06     Completed Date:  2013-04-10     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  101300215     Medline TA:  Dev Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1302-16     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. kanecynthiaj@uams.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fetal Alcohol Syndrome / immunology*,  physiopathology*
Fetus
Humans
Neuroimmunomodulation / immunology*
Pregnancy
Grant Support
ID/Acronym/Agency:
AA18834/AA/NIAAA NIH HHS; AA18839/AA/NIAAA NIH HHS; AA19108/AA/NIAAA NIH HHS; R01 AA018834/AA/NIAAA NIH HHS; R21 AA018839/AA/NIAAA NIH HHS; RC1 AA019108/AA/NIAAA NIH HHS
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