| Neuroimmune mechanisms in fetal alcohol spectrum disorder. | |
| | |
MedLine Citation:
|
PMID: 22623427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fetal alcohol spectrum disorder (FASD) is a major health concern worldwide and results from maternal consumption of alcohol during pregnancy. It produces tremendous individual, social, and economic losses. This review will first summarize the structural, functional, and behavior changes seen in FASD. The development of the neuroimmune system will be then be described with particular emphasis on the role of microglial cells in the normal regulation of homeostatic function in the central nervous system (CNS) including synaptic transmission. The impact of alcohol on the neuroimmune system in the developing CNS will be discussed in the context of several key immune molecules and signaling pathways involved in neuroimmune mechanisms that contribute to FASD. This review concludes with a summary of the development of early therapeutic approaches utilizing immunosuppressive drugs to target alcohol-induced pathologies. The significant role played by neuroimmune mechanisms in alcohol addiction and pathology provides a focus for future research aimed at understanding and treating the consequences of FASD. |
| | |
Authors:
|
Cynthia J M Kane; Kevin D Phelan; Paul D Drew |
Related Documents
:
|
21712157 - Maternal mcg interference cancellation using splined independent component subtraction. 21802737 - Prevalence and correlates of major depressive episode in pregnant and postpartum women ... 21890557 - Condyloma acuminatum: atypical presentation during pregnancy. 22102527 - Ultrasound safety in early pregnancy: reduced energy setting does not compromise obstet... 17895047 - Cranial sinus thrombosis and preeclampsia. 12113877 - Three-dimensional sonography for assessment of morphology and vascularization of the fe... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-09-01 |
Journal Detail:
|
Title: Developmental neurobiology Volume: 72 ISSN: 1932-846X ISO Abbreviation: Dev Neurobiol Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-09-06 Completed Date: 2013-04-10 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 101300215 Medline TA: Dev Neurobiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1302-16 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. kanecynthiaj@uams.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Female Fetal Alcohol Syndrome / immunology*, physiopathology* Fetus Humans Neuroimmunomodulation / immunology* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
|
AA18834/AA/NIAAA NIH HHS; AA18839/AA/NIAAA NIH HHS; AA19108/AA/NIAAA NIH HHS; R01 AA018834/AA/NIAAA NIH HHS; R21 AA018839/AA/NIAAA NIH HHS; RC1 AA019108/AA/NIAAA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel methods of myocardial protection and de-airing for complex descending aortic aneurysm surgery.
Next Document: Proteomic analysis of ?4?1 integrin adhesion complexes reveals ?-subunit-dependent protein recruitme...