| Neuroimmune aspects of the pathogenesis of Tourette's syndrome and experience in the use of immunoglobulins in children. | |
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MedLine Citation:
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PMID: 19621268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A total of 60 patients aged 6-16 years with tics and Tourette's syndrome were studied. Antibodies to caudate nucleus proteins were assayed by western blot hybridization. Ten patients with Tourette's syndrome were found to have antibodies to caudate nucleus protein. Seven patients with neuroleptic-resistant types of Tourette's syndrome received single transfusions of immunoglobulin preparations, which produced regression of vocal and motor hyperkinesias and improvement in behavior (remission for more than six months). The observation of antibodies to caudate nucleus proteins and the positive effects seen on administration of immunoglobulins to patients with Tourette's syndrome support previous data on the possibility of using immunoglobulin therapy in the treatment of tic-type hyperkinesias and provide evidence of the involvement of autoimmune mechanisms inducing damage to the dopaminergic system of the striatum. |
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Authors:
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V P Zykov; A Yu Shcherbina; E B Novikova; T V Shvabrina |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience and behavioral physiology Volume: 39 ISSN: 1573-899X ISO Abbreviation: Neurosci. Behav. Physiol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-07-30 Completed Date: 2009-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0330471 Medline TA: Neurosci Behav Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 635-8 Citation Subset: IM |
Affiliation:
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Department of Pediatric Neurology, Russian Postgraduate Medical Academy, Moscow, Russia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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immunology* Child Child, Preschool Female Globus Pallidus / immunology* Humans Immunoglobulins, Intravenous / therapeutic use* Male Tourette Syndrome / drug therapy*, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Immunoglobulins, Intravenous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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