| Neuroimaging parameters in early open spina bifida detection. Further benefit in first trimester screening? | |
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MedLine Citation:
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PMID: 21892523 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: Morphological investigation of the central nervous system (CNS) in fetuses with positive markers for open spina bifida (OSB) detection, visualized by ultrasound during the first trimester of pregnancy. Materials and Methods: Data from fetuses that underwent routine first trimester ultrasound scan in our center during September 2007-March 2011 and presented abnormal aspects of the fourth ventricle, also referred as intracranial translucency (IT), provided the morphological support to evaluate CNS features. A neuro-histological study of posterior cerebral fossa illustrated anatomical features of the structures involved in the sonographic first trimester detection of neural tube defects. Results: Abnormal IT aspects were found in OSB cases examined in the first trimester, but also in other severe cerebral abnormalities. Brain stem antero-posterior diameter (BS) and brain stem to occipital bone (BSOB) ratio may be more specific for OSB detection. Correlations between histological aspects of posterior brain fossa and ultrasound standard assessment have been made; highlighting the anatomical features involved by the new techniques developed for OSB early detection. Conclusions: Preliminary results show that modern sonographic protocols are capable to detect abnormalities in the morphometry of the posterior brain. First trimester fourth ventricle abnormalities should be followed by careful CNS evaluation because are likely to appear in OSB affected fetuses, but also in other CNS severe anomalies; in such cases, normal BS and BSOB ratio may serve as indirect argument for spine integrity, if specificity is confirmed in large series of fetuses. |
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Authors:
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D Iliescu; A Comănescu; P Antsaklis; Stefania Tudorache; Mirela Ghiluşi; Violeta Comănescu; Daniela Paulescu; Iuliana Ceauşu; A Antsaklis; Liliana Novac; N Cernea |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie Volume: 52 ISSN: 1220-0522 ISO Abbreviation: Rom J Morphol Embryol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112454 Medline TA: Rom J Morphol Embryol Country: Romania |
Other Details:
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Languages: eng Pagination: 809-17 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Prenatal Diagnostic Unit, University of Medicine and Pharmacy of Craiova, Romania; alexcom8000@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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