Document Detail

Neuroimaging in dementias.
MedLine Citation:
PMID:  23037962     Owner:  NLM     Status:  Publisher    
PURPOSE OF REVIEW: To critically review data on the use of neuroimaging tools in the clinical diagnostic investigation of dementias. RECENT FINDINGS: For many years, the use of neuroimaging tools in the evaluation of dementias has been restricted to excluding neurosurgical lesions that may account for the cognitive decline. However, modern neuroimaging extends beyond this traditional role of excluding other conditions and has a key role in the clinical investigation of Alzheimer's disease and of other degenerative cortical dementias. MRI, PET with fluorodeoxyglucose, and single-photon emission computed tomography are topographic markers of neural damage and enable the identification of specific lesional patterns that characterize Alzheimer's disease and other cortical dementias. More recently, PET amyloid markers have enabled the in-vivo assessment of amyloid load, a key feature in the physiopathology of Alzheimer's disease. SUMMARY: The combined use of neuroimaging examinations with clinical, neuropsychological, and cerebrospinal fluid markers can improve the specificity of the diagnosis of Alzheimer's disease, even at early stages of the disease. In the following years, progress in research will provide standardized and validated imaging markers of Alzheimer's disease and other dementias, which may increase their application in clinical settings.
Leonardo Cruz de Souza; Stéphane Lehéricy; Bruno Dubois; Florindo Stella; Marie Sarazin
Publication Detail:
Journal Detail:
Title:  Current opinion in psychiatry     Volume:  25     ISSN:  1473-6578     ISO Abbreviation:  Curr Opin Psychiatry     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809880     Medline TA:  Curr Opin Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  473-479     Citation Subset:  -    
aAlzheimer and Memory Institute; Research and Resource Memory Centre, AP-HP bCentre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie (UPMC)-Paris 06, Hôpital de la Pitié-Salpêtrière cINSERM, UMR-S 975 dCNRS, UMR 7225 eInstitut du Cerveau et de la Moelle épinière - ICM, Centre de NeuroImagerie de Recherche (CENIR), Hôpital de la Pitié-Salpêtrière fService de Neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France gUNESP - Universidade Estadual Paulista, Biosciences Institute, Campus of Rio Claro hLaboratory of Neurosciences, Institute of Psychiatry, University of São Paulo, Brazil.
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