| Neuroimaging findings in a case of fluoxetine overdose. | |
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MedLine Citation:
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PMID: 22197403 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Brain MRI and (18)F-FDG PET/CT scans were performed in a patient who had survived a suicide attempt by fluoxetine overdose. The patient presented with the following clinical signs and symptoms, and neuroimaging findings: severe signs of serotonin toxicity, including comatose state, akinetic rigid syndrome and dysautonomia; bilateral globus pallidus changes consistent with extensive pallidal necrosis and subsequent reversible diffuse ischemic changes in white matter, with posterior predominance, involving the splenium of the corpus callosum on brain MRI; and marked hypometabolism in the frontal, parietal and temporal cortical regions as well as in both caudate nuclei on (18)F-FDG PET/CT performed 37days later. These findings suggest that acute severe serotonin toxicity can induce structural and long-standing functional changes in multiple cortical and subcortical brain regions that are associated with cognitive and extrapyramidal syndromes. |
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Authors:
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Miklós Szólics; Muhammad Chaudhry; Milos Ljubisavljevic; Peter Corr; Hashim A Samir; Klaus Neidl van Gorkom |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-22 |
Journal Detail:
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Title: Journal of neuroradiology. Journal de neuroradiologie Volume: - ISSN: 0150-9861 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705086 Medline TA: J Neuroradiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Masson SAS. |
Affiliation:
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Neurology Division, Department of Medicine, Tawam Hospital, Al Ain, United Arab Emirates; Medicine Department, Faculty of Medicine and Health Science, UAE University, Al Ain, United Arab Emirates. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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