| Neuroimaging for drug addiction and related behaviors. | |
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MedLine Citation:
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PMID: 22117165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors. |
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Authors:
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Muhammad A Parvaz; Nelly Alia-Klein; Patricia A Woicik; Nora D Volkow; Rita Z Goldstein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-11-25 |
Journal Detail:
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Title: Reviews in the neurosciences Volume: 22 ISSN: 0334-1763 ISO Abbreviation: Rev Neurosci Publication Date: 2011 |
Date Detail:
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Created Date: 2011-12-14 Completed Date: 2012-03-27 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 8711016 Medline TA: Rev Neurosci Country: Germany |
Other Details:
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Languages: eng Pagination: 609-24 Citation Subset: IM |
Affiliation:
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Medical Department, Brookhaven National Laboratory, 30 Bell Ave., Bldg. 490, Upton, NY 11973-5000, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain*
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pathology,
physiopathology,
radionuclide imaging Cognition Disorders / etiology Electroencephalography Humans Mood Disorders / etiology Neuroimaging* Substance-Related Disorders / complications*, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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1R01DA023579/DA/NIDA NIH HHS; 5-MO1-RR-10710/RR/NCRR NIH HHS; M01 RR010710/RR/NCRR NIH HHS; R01 DA023579/DA/NIDA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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