| Neuroimaging of cortical development and brain connectivity in human newborns and animal models. | |
| | |
MedLine Citation:
|
PMID: 20979587 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Significant human brain growth occurs during the third trimester, with a doubling of whole brain volume and a fourfold increase of cortical gray matter volume. This is also the time period during which cortical folding and gyrification take place. Conditions such as intrauterine growth restriction, prematurity and cerebral white matter injury have been shown to affect brain growth including specific structures such as the hippocampus, with subsequent potentially permanent functional consequences. The use of 3D magnetic resonance imaging (MRI) and dedicated postprocessing tools to measure brain tissue volumes (cerebral cortical gray matter, white matter), surface and sulcation index can elucidate phenotypes associated with early behavior development. The use of diffusion tensor imaging can further help in assessing microstructural changes within the cerebral white matter and the establishment of brain connectivity. Finally, the use of functional MRI and resting-state functional MRI connectivity allows exploration of the impact of adverse conditions on functional brain connectivity in vivo. Results from studies using these methods have for the first time illustrated the structural impact of antenatal conditions and neonatal intensive care on the functional brain deficits observed after premature birth. In order to study the pathophysiology of these adverse conditions, MRI has also been used in conjunction with histology in animal models of injury in the immature brain. Understanding the histological substrate of brain injury seen on MRI provides new insights into the immature brain, mechanisms of injury and their imaging phenotype. |
| | |
Authors:
|
Gregory A Lodygensky; Lana Vasung; Stéphane V Sizonenko; Petra S Hüppi |
Related Documents
:
|
18941717 - Aging. 6811497 - Comparison and evaluation of osmotic blood-brain barrier disruption following intracaro... 7568567 - Midline abnormalities and psychopathology: how reliable is the midsagittal magnetic res... 18786567 - Improving segmentation accuracy for magnetic resonance imaging using a boosted decision... 2512777 - High-intensity basal ganglia lesions on t1-weighted mr images in neurofibromatosis. 12768917 - Magnetic resonance imaging guided cardiovascular interventions in congenital heart dise... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Journal of anatomy Volume: 217 ISSN: 1469-7580 ISO Abbreviation: J. Anat. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0137162 Medline TA: J Anat Country: England |
Other Details:
|
Languages: eng Pagination: 418-28 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors. Journal of Anatomy © 2010 Anatomical Society of Great Britain and Ireland. |
Affiliation:
|
NICU, Department of Pediatrics, University of Geneva, Geneva, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Populations of subplate and interstitial neurons in fetal and adult human telencephalon.
Next Document: Development of the cornea of true moles (Talpidae): morphogenesis and expression of PAX6 and cytoker...