Document Detail

Neurohumoral regulation of blood flow to bones and marrow.
MedLine Citation:
PMID:  495729     Owner:  NLM     Status:  MEDLINE    
We used labeled microspheres to measure bone and marrow blood flow under control conditions and during several interventions. In dogs, blood flow to compact cortical bone (femoral diaphysis) was 2 +/- 0.1 ml.min-1. 100 g-1, and in hematopoietic marrow (femur), flow was 24 +/- 5 ml.min-1. 100 g-1. Hematopoietic cancellous bones (sternum, ilium) received substantial blood flow. We estimate that as much as 11% of cardiac output is directed to the skeleton. Bone and marrow vessels were responsive to several stimuli. During exercise, vascular resistance in bone increased two- to fourfold, in contrast to profound vasodilation in adjacent skeletal muscle. Hemmorrhage also increased bone vascular resistance. Bone and marrow vessels responded to humoral stimuli: norepinephrine increased vascular resistance and adenosine decreased resistance. Bone vessels also responded to neural stimuli: stimulation of carotid baroreceptors decreased vascular resistance, and activation of sympathetic pathways by baroreceptor deafferentation in cats increased vascular resistance. These studies indicate that bone and marrow vessels respond actively to physiological stresses and to several humoral and neurogenic stimuli
P M Gross; D D Heistad; M L Marcus
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  237     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1979-12-27     Completed Date:  1979-12-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H440-8     Citation Subset:  IM; S    
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MeSH Terms
Bone Marrow / blood supply*
Bone and Bones / blood supply*
Cardiac Output
Norepinephrine / pharmacology*
Physical Exertion
Pressoreceptors / physiology
Regional Blood Flow
Vascular Resistance
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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