Document Detail

Neurohormonal regulation of histamine release from isolated rabbit fundic mucosal cells.
MedLine Citation:
PMID:  7692707     Owner:  NLM     Status:  MEDLINE    
Histamine-containing cells isolated from rabbit fundic mucosa were found in a small cell elutriation fraction (cells with diameter about 9-12 microns) enriched in mucus and endocrine cells and containing less than 1% mast cells (F1 cells). Gastrin (HG-17), pentagastrin and CCK-8 (C-terminal octapeptide of cholecystokinin) dose-dependently stimulated histamine release (EC50, respectively, 0.126 +/- 0.03, 0.92 +/- 0.15 and 0.211 +/- 0.025 nM) and somatostatin inhibited this release. PGE1, PGE2 and PGD2 alone were unable to enhance histamine release even at high concentrations but, when used in combination with gastrin of CCK-8, the release of histamine caused by these peptides was potentiated (about 1.5- to 2-fold). Carbachol also enhanced the liberation of histamine but with a weaker potency and efficacy than the gastrointestinal peptides (EC50: 1.50 +/- 0.06 microM). The use of specific muscarinic antagonists for M1-, M2- and M3-type receptors led us to conclude that an M1 receptor might be involved in the muscarinic-induced stimulation of histamine release. Activators of protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 1-oleyl-2-acetyl-glycerol (OAG) as well as the calcium ionophore, A23187, induced histamine release, whereas agents which increased intracellular cAMP content were devoid of effect.(ABSTRACT TRUNCATED AT 250 WORDS)
F Hollande; T Gusdinar; J P Bali; R Magous
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Agents and actions     Volume:  38     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-11-05     Completed Date:  1993-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  149-57     Citation Subset:  IM    
Laboratoire de Biochimie des Membranes, Faculté de Pharmacie, Montpellier, France.
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MeSH Terms
1-Methyl-3-isobutylxanthine / pharmacology
Bucladesine / pharmacology
Calcimycin / pharmacology
Carbachol / pharmacology
Diglycerides / pharmacology
Dose-Response Relationship, Drug
Forskolin / pharmacology
Gastric Fundus
Gastric Mucosa / cytology,  drug effects*,  secretion
Gastrins / pharmacology*
Histamine Release / drug effects*
Muscarinic Antagonists
Prostaglandins / pharmacology*
Sincalide / pharmacology*
Somatostatin / pharmacology*
Tetradecanoylphorbol Acetate / pharmacology
Reg. No./Substance:
0/Diglycerides; 0/Gastrins; 0/Muscarinic Antagonists; 0/Prostaglandins; 16561-29-8/Tetradecanoylphorbol Acetate; 25126-32-3/Sincalide; 28822-58-4/1-Methyl-3-isobutylxanthine; 362-74-3/Bucladesine; 51-83-2/Carbachol; 51110-01-1/Somatostatin; 52665-69-7/Calcimycin; 66428-89-5/Forskolin; 86390-77-4/1-oleoyl-2-acetylglycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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