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Neurohormonal control of heart failure.
MedLine Citation:
PMID:  21972336     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
For nearly three decades, starting in the early 1970s, the cardiology research laboratories at the University of Minnesota served as the focal point for the discovery and implementation of much of the information we now apply to the management of heart failure. Director Jay Cohn, building on his expertise in hypertension and hemodynamics, led many creative and committed investigators in the exploration of the mechanisms responsible for increased sensitivity to afterload in heart failure. The neurohormonal hypothesis of heart failure led to the development of several pharmacologic tools, such as angiotensin-converting enzyme inhibitors, β-adrenergic blockers, and, later, angiotensin-receptor blockers. By the late 1990s, it was understood that neurohormonal antagonists could prevent the progression of left ventricular remodeling and favorably influence the natural history of heart failure. Neurohormonal blockers are now considered standard therapy. Issues remain to be addressed, including early identification and treatment of patients at risk.
Authors:
Gary S Francis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cleveland Clinic journal of medicine     Volume:  78 Suppl 1     ISSN:  1939-2869     ISO Abbreviation:  Cleve Clin J Med     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703441     Medline TA:  Cleve Clin J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S75-9     Citation Subset:  IM    
Affiliation:
University of Minnesota Medical School, 284 VCRC, 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455; franc354@umn.edu.
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