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Neurohormonal Activation in Acute Heart Failure: Results from VERITAS.
MedLine Citation:
PMID:  21912122     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives: Recent heart failure studies have suggested that inflammatory and immune system activation are associated with increased levels of cytokines, chemokines and inflammatory proteins during acutely decompensated heart failure. The objectives of this substudy were to evaluate the role of neurohormonal and inflammatory activation in the pathogenesis and outcome of acute heart failure (AHF) and the correlation between biomarker levels and clinical outcomes. Methods: Serum levels of B-type natriuretic peptide-32 (BNP-32), endothelin-1 (ET-1), norepinephrine, troponins I and T, C-reactive protein (CRP), von Willebrand factor, plasminogen activator inhibitor-1, interleukin-6 (IL-6) and tissue plasminogen activator (TPA) were measured at baseline, 24 and 48 h and 7 and 30 days in 112 patients with AHF recruited to the Value of Endothelin Receptor Inhibition with Tezosentan in Acute Heart Failure Study neurohormonal substudy. Results: On univariable analysis, CRP, BNP and ET-1 were predictive of worsening heart failure by day 30; when considered together, only CRP and BNP were significantly associated with this outcome. On adjustment for age, baseline blood pressure, serum sodium and serum creatinine, only age and BNP remained significant. CRP, IL-6 and TPA levels were significantly correlated with 180-day mortality on univariable analysis. Conclusion: Circulating markers of inflammation may be useful in gauging prognosis in patients with AHF.
Authors:
Olga Milo-Cotter; Beth Cotter-Davison; Carlo Lombardi; Hengrui Sun; Luca Bettari; Silvia Bugatti; Michele Rund; Marco Metra; Edo Kaluski; Isaac Kobrin; Aline Frey; Maurizio Rainisio; John J V McMurray; John R Teerlink; Gad Cotter-Davison
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-08
Journal Detail:
Title:  Cardiology     Volume:  119     ISSN:  1421-9751     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  96-105     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Momentum Research Inc., Durham, N.C.,USA.
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