| Neurogliaform cells and other interneurons of stratum lacunosum-moleculare gate entorhinal-hippocampal dialogue. | |
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MedLine Citation:
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PMID: 21135049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The stratum lacunosum-moleculare of the hippocampus is an area of integration that receives inputs from extrinsic excitatory fibres including those from the entorhinal cortex, and is under the control of several neuromodulators. A critical aspect is the presence in this hippocampal layer of specific interneurons that are likely to influence the strength and the temporal structure of entorhinal-CA1 hippocampal dynamics. I review here recent data on the physiological role of these interneurons. Special focus is devoted to one interneuron type, the so-called neurogliaform cell, because recent studies have defined its unusual mode of cell-to-cell communication. Neurogliaform cells mediate feedforward inhibition of CA1 pyramidal cells, form a network of cells connected via chemical and electrical synapses, and evoke slow inhibitory synaptic currents mediated by GABA(A) and GABA(B) receptors. The modulation of entorhinal input by neurogliaform cells and their contribution to network theta rhythm are also discussed. I hope that novel information on neurogliaform cells will contribute to the ever-growing appreciation of GABAergic cell type diversity, and will inspire neuroscientists interested not only in synaptic physiology but also in the brain's spatial representation system. |
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Authors:
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Marco Capogna |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-12-06 |
Journal Detail:
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Title: The Journal of physiology Volume: 589 ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-18 Completed Date: 2011-08-09 Revised Date: 2012-09-20 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 1875-83 Citation Subset: IM |
Affiliation:
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MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK. marco.capogna@pharm.ox.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Feedback, Physiological* Hippocampus / metabolism, physiology* Humans Interneurons / metabolism, physiology* Nerve Net / physiology Neural Inhibition Neural Pathways / metabolism, physiology* Neuroglia / metabolism, physiology* Receptors, GABA-A / metabolism Receptors, GABA-B / metabolism Synaptic Transmission Theta Rhythm gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Receptors, GABA-A; 0/Receptors, GABA-B; 56-12-2/gamma-Aminobutyric Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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