| Neurogenic vasodilation and release of calcitonin gene-related peptide (CGRP) from perivascular nerves in the rat mesenteric artery. | |
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MedLine Citation:
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PMID: 2610699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of perivascular nerve stimulation (PNS) on the release of calcitonin gene-related peptide (CGRP) was examined by radioimmunoassay (RIA) in isolated, perfused rat mesenteric arteries. The released CGRP-like immunoreactivity (CGRP-LI) was identified to be CGRP itself and its oxidized form by combined analysis with RIA and high performance liquid chromatography. CGRP-LI was localized in the perivascular nerves of the large mesenteric artery and its branches. In the preparation precontracted by methoxamine, and perfused with a solution containing guanethidine, an adrenergic neuron blocker, PNS induced vasodilator responses and an increase of CGRP-LI in the perfusate in a frequency-dependent manner. Both the responses were attenuated by tetrodotoxin (10(-6) M), suggesting that they were neurogenic in origin. Removal of Ca2+ from the perfusing solution also abolished the PNS-induced release of CGRP-LI. These findings suggest that CGRP plays a transmitter role in the neurogenic vasodilation in the rat mesenteric vascular bed. |
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Authors:
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A Fujimori; A Saito; S Kimura; T Watanabe; Y Uchiyama; H Kawasaki; K Goto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 165 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-02-13 Completed Date: 1990-02-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1391-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Tsukuba, Ibaraki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcitonin Gene-Related Peptide / secretion* Calcium / physiology Chromatography, High Pressure Liquid Electric Stimulation Male Mesenteric Arteries / innervation*, physiology Nerve Fibers / physiology Radioimmunoassay Rats Rats, Inbred Strains Tetrodotoxin / pharmacology Vasodilation / physiology* |
| Chemical | |
Reg. No./Substance:
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4368-28-9/Tetrodotoxin; 7440-70-2/Calcium; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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