Document Detail


Neurogenic regulation of coronary blood flow: evidence for a central nervous system pathway.
MedLine Citation:
PMID:  2444359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The central representation of neurogenically mediated coronary vasoconstriction produced by activation of the sympathetic nervous system was examined in anesthetized cats instrumented for continuous recording of coronary and femoral blood flows, arterial pressure, and heart rate. Electrical stimulation in a small region of perifornical lateral hypothalamus increased arterial pressure, heart rate, and coronary blood flow; following the administration of propranolol, a transient coronary vasoconstrictor response was unmasked. The response was mediated over the sympathetic nervous system since it was blocked by stellate ganglionectomy and by the alpha 1-adrenergic receptor antagonist prazosin. Projections to and from the lateral hypothalamic site were identified by using anterograde and retrograde pathway-tracing techniques. Paraventricular nucleus projected to lateral hypothalamus, which in turn made connections in periaqueductal gray with projections terminating in lateral reticular formation of medulla. Coronary vasoconstrictor responses qualitatively identical to those produced by hypothalamic stimulation were found with activation of paraventricular nucleus and lateral reticular formation. Interruption of neuronal transmission in the medullary site blocked the response produced by activation of hypothalamic site. These data demonstrate that coronary vasoconstriction mediated over the sympathetic nervous system can be elicited from an interconnected pathway that links sympathoexcitatory sites in forebrain and brainstem.
Authors:
A C Bonham; D D Gutterman; J M Arthur; M L Marcus; G F Gebhart; M J Brody
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  61     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-15     Completed Date:  1987-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  II42-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Iowa, Iowa City 52242.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axonal Transport
Blood Flow Velocity
Blood Pressure
Cats
Coronary Circulation*
Electric Stimulation
Heart Rate
Horseradish Peroxidase
Neural Pathways / anatomy & histology,  physiology
Prazosin / pharmacology
Propranolol / pharmacology
Receptors, Adrenergic, alpha / physiology
Sympathectomy
Sympathetic Nervous System / physiology*
Vascular Resistance
Vasoconstriction* / drug effects
Wheat Germ Agglutinins
Grant Support
ID/Acronym/Agency:
HL-07001/HL/NHLBI NIH HHS; HL-14388/HL/NHLBI NIH HHS; HL-32295/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, alpha; 0/Wheat Germ Agglutinins; 19216-56-9/Prazosin; 525-66-6/Propranolol; EC 1.11.1.-/Horseradish Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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