Document Detail


Neurogenic pulmonary edema.
MedLine Citation:
PMID:  8316188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathogenesis of nervous system-induced pulmonary edema remains incompletely understood. There are two major causes: elevated intravascular pressure and pulmonary capillary leak. Thus, both hemodynamic (cardiogenic) or nonhemodynamic (noncardiogenic) components exist. These components often occur together in settings such as pulmonary edema following epileptic convulsions or intracranial pressure elevation. The hemodynamic component is relatively brief and may unmask a "pure" noncardiogenic pulmonary edema such as that seen in experimental seizures (see Fig. 6). Whether the hemodynamic changes produce a pulmonary capillary leak through pressure-induced mechanical injury to the pulmonary capillaries or whether some direct nervous system control over pulmonary capillary permeability exists remains uncertain. The neuroeffector site for nervous system-induced pulmonary edema appears relatively well established in regions about the caudal medulla, where nuclei regulating systemic arterial pressure and afferent and efferent pathways to and from the lungs are located.
Authors:
R P Simon
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurologic clinics     Volume:  11     ISSN:  0733-8619     ISO Abbreviation:  Neurol Clin     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-27     Completed Date:  1993-07-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8219232     Medline TA:  Neurol Clin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  309-23     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of California, San Francisco.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects,  physiopathology,  radiography
Brain Diseases / complications,  diagnosis
Epilepsy
Epinephrine / diagnostic use
Female
Humans
Hypothalamus / drug effects,  physiopathology
Lung / physiology,  physiopathology*
Lung Diseases / diagnosis,  etiology,  physiopathology*
Magnetic Resonance Imaging
Male
Pulmonary Edema / diagnosis,  etiology,  physiopathology*
Rats
Chemical
Reg. No./Substance:
51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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