Document Detail


Neurogenic neuroprotection: clinical perspectives.
MedLine Citation:
PMID:  23597434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurogenic neuroprotection is a promising approach for treating patients with ischemic brain lesions. In rats, stimulation of the deep brain nuclei has been shown to reduce the volume of focal infarction. In this context, protection of neural tissue can be a rapid intervention that has a relatively long-lasting effect, making fastigial nucleus stimulation (FNS) a potentially valuable method for clinical application. Although the mechanisms of neuroprotection induced by FNS remain partially unclear, important data have been presented in the last two decades. A 1-h electrical FNS reduced, by 59%, infarctions triggered by permanent occlusion of the middle cerebral artery in Fisher rats. The acute effect of electrical FNS is likely mediated by a prolonged opening of potassium channels, and the sustained effect appears to be linked to inhibition of the apoptotic cascade. A better understanding of the neuronal circuitry underlying neurogenic neuroprotection may contribute to improving neurological outcomes in ischemic brain insults.
Authors:
Mauricio Mandel; Erich Talamoni Fonoff; Edson Bor-Seng-Shu; Manoel Jacobsen Teixeira; Gerson Chadi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Functional neurology     Volume:  27     ISSN:  0393-5264     ISO Abbreviation:  Funct. Neurol.     Publication Date:    2012 Oct-Dec
Date Detail:
Created Date:  2013-04-19     Completed Date:  2013-06-18     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8707746     Medline TA:  Funct Neurol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  207-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Infarction / etiology,  prevention & control*
Cerebellar Nuclei / anatomy & histology,  metabolism,  physiology*
Cerebrovascular Circulation / physiology
Deep Brain Stimulation / methods*
Disease Models, Animal
Encephalitis / etiology,  prevention & control
Humans
Infarction, Middle Cerebral Artery / complications
Neural Pathways / physiology
Parietal Lobe / physiology
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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