Document Detail

Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?
MedLine Citation:
PMID:  22562144     Owner:  NLM     Status:  MEDLINE    
There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.
Matthew J Cates; C John Dickinson; Emma C J Hart; Julian F R Paton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  14     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-10-16     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-9     Citation Subset:  IM    
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MeSH Terms
Basilar Artery / physiopathology*
Brain Stem / blood supply*,  physiopathology
Hypertension / etiology*
Rats, Inbred SHR
Sympathetic Nervous System / physiopathology*
Vascular Resistance / physiology*
Vertebral Artery / physiopathology*
Grant Support
FS/11/1/28400//British Heart Foundation; HL033610/HL/NHLBI NIH HHS; MC_G0900868//Medical Research Council; RG/07/006/23634//British Heart Foundation; //British Heart Foundation

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