Document Detail


Neurogenesis and development of callosal and intracortical connections in the hamster.
MedLine Citation:
PMID:  2175019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The developmental time-course of callosal and ipsilateral corticocortical projections was studied in embryonic and postnatal hamsters, from the time of neurogenesis until the appearance of adult patterns. Callosal neurogenesis was determined by combining the incorporation of [3H]thymidine injected on specific embryonic days with retrograde labelling of callosal neurons in the adult animal. The development of both callosal and corticocortical projections was studied by the transport of wheat germ agglutinin conjugated to horseradish peroxidase. Despite a significant radial disperson of postmigratory neurons born on the same day, it was found that the birthdates of callosally-projecting neurons in the frontal cortex were not restricted to a short period of time, but extended between embryonic days 13 and 15. This period covers the neurogenesis of cells in cortical layers III-V. Elongation of callosal axons (and possibly also of corticocortical fibres) started a couple of days before birth in the frontal cortex, and continued through the first postnatal days. After a "waiting period" of a few days, axons from both sets of projections were seen innervating restricted target sectors of the cortex. The zones of origin of these projections were initially exuberant, but were subsequently trimmed to overlap completely with the corresponding terminal fields. It is concluded that callosal and ipsilateral corticocortical projections undergo similar sequences of ontogenetic stages, suggesting that the development of neocortical connectivity as a whole may be governed by one and the same set of rules.
Authors:
R Lent; C Hedin-Pereira; J R Menezes; S Jhaveri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience     Volume:  38     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1990  
Date Detail:
Created Date:  1991-01-24     Completed Date:  1991-01-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  21-37     Citation Subset:  IM    
Affiliation:
Instituto de Biofisica Carlos Chagas Filho, UFRJ, Rio de Janeiro, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Cerebral Cortex / growth & development*
Corpus Callosum / growth & development*
Cricetinae
Horseradish Peroxidase / diagnostic use
Mesocricetus
Neural Pathways / growth & development
Synaptic Transmission
Thalamus / growth & development
Thymidine / diagnostic use
Wheat Germ Agglutinins / diagnostic use
Grant Support
ID/Acronym/Agency:
EY05504/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Wheat Germ Agglutinins; 50-89-5/Thymidine; EC 1.11.1.-/Horseradish Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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