| Neurofilament heavy-chain NfH(SMI35) in cerebrospinal fluid supports the differential diagnosis of Parkinsonian syndromes. | |
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MedLine Citation:
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PMID: 17013909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aimed to evaluate the potential of the cerebrospinal fluid (CSF) axonal damage biomarker NfH(SMI35) in the laboratory-supported differential diagnosis of parkinsonian syndromes. Patients with idiopathic Parkinson's disease (PD; n = 22), multiple-system atrophy (MSA; n = 21), progressive supranuclear palsy (PSP; n = 21), corticobasal degeneration (CBD; n = 6), and age-matched controls (n = 45) were included. CSF levels of NfH(SMI35) were measured using ELISA. Levels of CSF NfH(SMI35) were elevated in PSP compared to PD and controls (P < 0.05 each). They were also significantly higher in MSA than in PD and controls (P < 0.05 each). NfH(SMI35) differentiated PD from PSP with a sensitivity of 76.5% and a specificity of 94.4%. Axonal damage as measured by CSF NfH(SMI35) is most prominent in the more rapidly progressive syndromes PSP and MSA as compared to PD or CBD. CSF NfH(SMI35) may therefore be of some value for the laboratory-supported differential diagnosis of atypical parkinsonian syndromes. |
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Authors:
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Johannes Brettschneider; Axel Petzold; Sigurd D Süssmuth; Georg B Landwehrmeyer; Albert C Ludolph; Jan Kassubek; Hayrettin Tumani |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 21 ISSN: 0885-3185 ISO Abbreviation: Mov. Disord. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-27 Completed Date: 2007-02-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 2224-7 Citation Subset: IM |
Copyright Information:
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Copyright 2006 Movement Disorder Society. |
Affiliation:
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Department of Neurology, University of Ulm, Ulm, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Case-Control Studies Diagnosis, Differential Enzyme-Linked Immunosorbent Assay / methods Female Humans Male Middle Aged Multiple System Atrophy / cerebrospinal fluid Neurofilament Proteins / cerebrospinal fluid* Parkinsonian Disorders / cerebrospinal fluid*, diagnosis* ROC Curve Supranuclear Palsy, Progressive / cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
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0/Neurofilament Proteins; 108688-71-7/neurofilament protein H |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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