Document Detail


Neurofibromatosis type 1: a case report and review of the literature.
MedLine Citation:
PMID:  1578214     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurofibromatosis is the most common single-gene disorder of the nervous system. The chromosomal defects for at least two forms of neurofibromatosis have been delineated and mapped to chromosomes 17 (type 1) and 22 (type 2). The clinical course for either type of neurofibromatosis is unpredictable, and serious neurologic and systemic manifestations frequently arise in patients with this disorder. A 66-year-old woman presented with rapidly progressive myelopathy requiring operative decompression of the spinal canal to preserve function of the lower extremities. It is important to recognize the characteristics of neurofibromatosis and understand the natural history of this condition. Conservative treatment is the rule, treating new manifestations as they arise.
Authors:
W S Holt; D M Harsha
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Journal of family practice     Volume:  34     ISSN:  0094-3509     ISO Abbreviation:  J Fam Pract     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-06-08     Completed Date:  1992-06-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7502590     Medline TA:  J Fam Pract     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  617-24     Citation Subset:  AIM; IM    
Affiliation:
Department of Family Medicine, Indiana University, School of Medicine, Indianapolis.
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Humans
Neurofibromatosis 1* / complications,  therapy
Spinal Cord Compression / etiology
Spinal Cord Neoplasms* / complications

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